类叶升麻的化学成分研究  

Study on chemical constituents from rhizomes of Actaea asiatica

作　　者：高璟春[1,2] 张金超[3,4] 陈瑶[2] 杨梦苏[2,3] 肖培根[1] 

机构地区：[1]中国医学科学院,中国协和医科大学,药用植物研究所 [2]香港城市大学深圳研究院,广东深圳518057 [3]香港城市大学生物及化学系 [4]河北大学化学与环境科学学院化学系,河北保定071002

出　　处：《中国中药杂志》2007年第21期2256-2259,共4页China Journal of Chinese Materia Medica

基　　金：国家自然科学基金项目(30530860)

摘　　要：目的:研究我国药用植物类叶升麻Actaea asiatica根茎的化学成分,为阐明其有效成分提供依据。方法:利用硅胶柱色谱,反相柱色谱,半制备液相进行分离,根据化合物的光谱数据(IR,MS,1H-NMR,13C-NMR)和化学方法鉴定其结构。结果:从根茎的醋酸乙酯萃取物中分离得到6个化合物,分别鉴定为25-O-乙酰升麻醇(1),12β-羟基升麻醇(2),23-epi-26-deoxyactein(3),27-deoxyacetylacteol(4),26-deoxycimicifugenin(5)及β-谷甾醇(6)。结论:以上化合物均为首次从该属植物中分离得到。Objective： To investigate the chemical constituents of the rhizomes of Actaea asiatica in order to obtain a more comprehensive understanding of its effective components. Method： Compounds were separated by silica gel chromatography, RP-C18 chromatography and semi-preparative high performance liquid chromatography, and their structures were established by spectral analysis and chemical evidence. Result： Six compounds were isolated from the ethyl acetate extract. Their structures were identified as 25-O- acetylcimigenol （ 1 ）, 12β-hydroxycimigenol （2）, 23-epi-26-deoxyactein （3）, 27-deoxyacetylacteol （4）, 26-deoxycimicifugenin （5） and/β-sitosterol （6）. Conclusion： All these compounds mentioned above were isolated from the plant for the first time.

关 键 词：类叶升麻 化学成分 

分 类 号：R284.1[医药卫生—中药学]