注射用生脉对心源性休克的影响  

Effects of Shengmai for injection on cardiogenic shock

作　　者：丁晓飞 陈光[2] 刘玉兰[2] 

机构地区：[1]辽宁省药品检验所药理室,辽宁沈阳110023 [2]沈阳药科大学药学院,辽宁沈阳110016

出　　处：《中国中药杂志》2007年第21期2298-2305,共8页China Journal of Chinese Materia Medica

摘　　要：目的:考察注射用生脉对心源性休克的保护作用及作用机制。方法:采用结扎冠状动脉造成犬急性心源性休克模型,测定犬心脏血流动力学参数、心肌梗死面积和血清乳酸脱氢酶(LDH)、磷酸肌酸肌酶(CK)、超氧化物歧化酶(SOD)活力及丙二醛(MDA)含量。结果:注射用生脉可显著升高心源性休克犬的平均动脉压(MBP)、心率(HR)、左室内压(LVP)、左室内压最大上升及下降变化率(±dp/dtm ax)、心输出量(CO)和心脏指数(C I),明显降低犬左室舒张末期压(LVEDP)和总外周阻力(TPVR);缩小心肌梗死范围,降低血清中LDH,CK活力及MDA含量,升高SOD活力。结论:注射用生脉对心源性休克具有保护作用。Objective： To study the protective effects and the possible mechanism of shengmai for injection（SM） against the experimental acute cardiogenic shock. Method： The experimental acute cardiogenic shock model was established by ligating the anterior descending cornonary in dogs. The effects of SM on cardiogenic shock were investigated by measuring the hemodynamics parameter, the activity of LDH, CK, SOD and the contents of MDA in blood serum. Result： In the dogs treated with SM, the mean arterial pressure （MAP）, heart rate （HR）, left ventricular pressure （LVP）, the maximum of its first derivative （ ± dp/dtmax）, the cardiac output （CO） and the cardiac index （CI） were increased significantly. The left ventricular end diastolic pressure （LVEDP） and the peripheral vascular resistance （TPVR） were decreased significantly, the myocardial infarct size was redused observely. In addition, the activity of LDH, CK and the contents of MDA in serum were decreased significantly, however the activity of SOD was increased observely. Conclusion： The results indicate that SM has the protective effects on cardiogenic shock.

关 键 词：注射用生脉 心源性休克 犬 心脏血流动力学 心肌梗死范围 心肌酶谱 

分 类 号：R285.5[医药卫生—中药学]