清开灵分散片处方及制备工艺研究  

Study on Formulation and Preparation Technology of Qingkailing Dispersible Tablets

作　　者：刘明[1] 王慧森[1] 任孝德[1] 李更生[1] 

机构地区：[1]河南省中医药研究院,郑州450004

出　　处：《中国药师》2007年第11期1065-1067,共3页China Pharmacist

摘　　要：目的:考察清开灵分散片的制备工艺和最优处方。方法:以分散时间为考察指标,采用正交设计试验对清开灵分散片处方进行筛选。结果:以微晶纤维素为填充剂,微粉硅胶为助流剂,硬脂酸镁为润滑剂,3%的交联聚乙烯吡咯烷酮、6%的低取代羧丙基纤维素和5%的羧甲基淀粉钠为崩解剂,湿法制粒制备分散片。结论:本法研制的清开灵分散片处方合理,工艺可行。Objective： To investigate the preparation technique and optimal formulation of Qingkailing dispersible tablets. Method： The formula of Qingkailing dispersible tablets was optimized in terms of disintegrating time by orthogonal design test. Result： The tablets was prepared by compressing moist granulation, the microcrystalling cellulose （ MCC ） as the bulking agent, the micro mist blangel as the glidant, the magnesium stearate （MS） as the lubricating agent and the crosslinking polyvinyl polypyrrolidone （3%, CPVPP）, low displacement carboxyl propyl cellulose （6% , L-HPC ） and sodium carboxymethyl starch （5% , CMS-Na） as the disintegrating agent were taken. Conclusion： The prescription and technology of Qingkailing dispersible tablets were reasonable and effective.

关 键 词：清开灵分散片 分散时间 制备工艺 

分 类 号：R283[医药卫生—中药学]