青翘片中阿司匹林的含量测定  

Determination the Content of Aspirin in Qingqiao Tablets

作　　者：王丽丽[1] 李任[1] 沈素[1] 

机构地区：[1]首都医科大学附属北京友谊医院,北京100050

出　　处：《中国药师》2007年第11期1109-1111,共3页China Pharmacist

摘　　要：目的:建立青翘片中阿司品林含量测定方法。方法:色谱柱:Shim-pack CLC C_(18)(150 mm×4.6 mm,5μm);流动相:乙腈:0.08 mol·L^(-1)醋酸钠溶液(冰醋酸调pH至3.65)(15:85),流速:2 ml·min^(-1),检测波长:230 nm。紫外分光光度法检测波长:300 nm。结果:高效液相法:阿司匹林的线性范围为2～10μg·ml^(-1)(r=0.9999),回收率100.5%,RSD为0.8%(n= 6)。紫外分光光度法:阿司匹林在5～30μg·ml^(-1)呈线性,平均回收率为100.9%,RSD为0.6%(n=5)。结论:两种方法均适用于青翘片中阿司匹林的含量测定。Objective： To determine the Aspirin in Qingqiao tablets. Method： HPLC： Shim-pack CLC C18 column （ 150mm×4. 6mm,5um） was used . The mobile phase consisted of aeetonitrile-0. 08 mol·L^-1 sodium acetate solution （adjusted pH to 3.65 with glacial acetic acid） （15： 85）, The flow rate was 2 ml-min^-1. The detection wavelength was at 230 nm, UV speetrophotometrie： The detection wavelength was at 300 nm. Result： HPLC ：The linear rang of Aspirin was 2 - 10 μg·ml^-1 （r = 0. 999 9）. The average recovery of Aspirin was 100.5% （RSD = 0. 8 % , n = 6 ）. Ultraviolet spectrophotometry： The linear rang of Aspirin was 5 -30 μg·ml^-1（ r = 0. 999 9）. The average recovery was 100.9% （RSD =0.6% ,n =5）. Conclusion： HPLC and UV speetrophotometry can be both used to determine Asipirin in Qingqiao tabalets.

关 键 词：青翘片 高效液相色谱 紫外分光光度法 阿司匹林 含量测定 

分 类 号：R927.2[医药卫生—药学]