加替沙星序贯治疗下呼吸道感染疗效评价  

Clinical Evalution of Sequential Therapy of Gatifloxacin and Levofloxacin on Treatment of Lower Respiratory Tract Infection

作　　者：苗佩宏[1] 竺顺斌[1] 

机构地区：[1]武警浙江省总队医院,浙江嘉兴314000

出　　处：《中国药师》2007年第11期1125-1127,共3页China Pharmacist

摘　　要：目的:评价加替沙星静滴、加替沙星静滴和左氧氟沙星口服序贯治疗下呼吸道感染的疗效和安全性。方法:将256例下呼吸道感染患者随机分为2组,其中对照组应用加替沙星注射液400 mg静滴,qd;序贯组用加替沙星注射液400 mg静滴qd,3 d后改为口服左氧氟沙星片400 mg,qd,疗程均为7～14 d。结果:对照组和序贯组总有效率分别为89.84%与85.94%,细菌清除率分别为95.33%与92.45%,药物不良反应发生率分别为8.59%与7.81%,其结果均无经统计学差异(P>0.05)。结论:加替沙星、左氧氟沙星序贯治疗下呼吸道感染具有与单用加替沙星静滴相似的临床疗效,但比单用依从性好。Objective： To evaluate the clinical efficacy and safety of sequential therapy of gatifloxacin and levofloxacin in the treatment of lower respiratory tract infections（LRTI）. Method： A total of 256 in-patients with LRTI were divided into two groups randomly, the control group used gatifloxacin 400 mg ivd, qd and the sequatial group used gatifloxacin 400 mg ivd,qd once daily for 3 days and subsequently oral levofloxacin 400 mg qd. The total duration of therapy was 7 - 14 days. Result： The clinical total efficacy rate was 89.84% in control group, and 85.94% in sequential group, respectively. The bacterial eradication rate was 95.33% and 92.45% respectively, and the adverse drug reaction rate was 8.59% and 7.81% respectively. There were no statistical difference between two groups （ P 〉 0.05 ）. Conclusion ： The efficacy of sequential therapy with gatifloxacin and levofloxaxin is equivalence to monotherapy of gatifloxacin.

关 键 词：加替沙星 左氧氟沙星 下呼吸道感染 序贯治疗 

分 类 号：R978.1[医药卫生—药品]