肝移植术后急性排斥反应中Th1/Th2变化的研究  

Changes of Th1/Th2 in acute rejection after liver tranplantation

作　　者：郝建宇[1] 裴艳香[1] 夏成青[1] 齐曼[1] 

机构地区：[1]首都医科大学附属北京朝阳医院消化内科,100020

出　　处：《肝脏》2007年第5期360-362,共3页Chinese Hepatology

摘　　要：目的探讨肝移植术后患者Th1/Th2在急性排斥反应中的变化及意义。方法采用双色流式细胞术分析21例肝移植患者手术前后外周血中的Th1细胞和Th2细胞的百分率,并计算Th1/Th2的变化。结果肝移植术后急性排斥过程中Th1细胞较术前有显著性升高,Th2细胞较术前无显著性变化,Th1/Th2较术前有显著性升高。排斥组与非排斥组相比,Th1/Th2有显著性升高。急性排斥时及排斥前Th1/Th2与术前相比有显著性差异。结论Th1/Th2的变化与肝移植急性排斥反应的发生密切相关。Objective To investigate the changes of Th1,Th2,Th1/Th2 in acute rejection after liver transplantation. Methods The peripheral blood of 21 patients with liver transplantation were collected and stimulated by PMA/Ionomycin/monensin. changes of Thl and Th2 were detected by immune fluorescence staining cytokine in cells and flow cytometry, the changes of Thl/Th2 was analyse . Results The Thl and Thl/Th2 significantly elevated during the acute rejection period, But Th2 did not change obviously at the same time. Comparing with the non-acute rejection group, Thl/Th2 of the acute rejection group elevated significantly . Thl/Th2 elevated significantly in the days before the acute rejection. Conclusion The change of Thl/Th2 was correlated with the occurrence of acute rejection, change of Thl/Th2 is a simple and effective method for mornitoring the acute rejection in patients with liver transplantation

关 键 词：肝移植 TH1细胞 TH2细胞 TH1/TH2 

分 类 号：R657.3[医药卫生—外科学]