3-(2-苯并呋喃酰基)薁-1-羧酸甲酯的有效合成  

Efficient Synthesis of Methyl 3-(2-Benzo[b]furoyl)azulene- 1 -carboxylates

作　　者：王道林[1] 徐姣[1] 谷峥[1] 韩珊[1] 

机构地区：[1]渤海大学化学化工学院辽宁省应用化学重点实验室,锦州121003

出　　处：《有机化学》2007年第11期1404-1408,共5页Chinese Journal of Organic Chemistry

基　　金：辽宁省教育厅科学研究计划(No.2005021)资助项目

摘　　要：以苯基三甲铵三溴盐(PTAB)为溴化试剂,对3-乙酰基薁-1-羧酸甲酯进行了溴代反应研究,将其单溴代产物与水杨醛在温和反应条件下进行缩合,以极优的收率高选择性得到3-(2-苯并[b]呋喃酰基)薁-1-羧酸甲酯类衍生物,其结构经1H NMR,IR及元素分析等得以证实.Methyl 3-（2-benzo[b]furoyl）azulene-l-carboxylate derivatives were synthesized by the condensation of methyl 3-（bromoacetyl）azulene-lcarboxylate with salicylaldehydes under mild conditions with ex- cellent yields. The bromination conditions of methyl 3-acetylazulene-l-carboxylate with phenyltrimethylammonium perbromide were discussed. All the compounds were fully characterized by ^1H NMR, IR spectra and elemental analysis.

关 键 词：薁 苯并[b]呋喃 溴代 苯基三甲铵三溴盐(PTAB) 水杨醛 合成 

分 类 号：O626.11[理学—有机化学]