脱氢表雄酮对肉鸡脂类代谢和相关激素的影响  

Effect of Dehydroepiandrosterone on Lipid Metabolism and Related Hormones in Broilers

作　　者：田朝阳[1] 邹思湘[1] 陈伟华[1] 马海田[1] 

机构地区：[1]南京农业大学动物医学院,南京210095

出　　处：《农业生物技术学报》2007年第5期778-782,共5页Journal of Agricultural Biotechnology

基　　金：国家自然科学基金(No.30600439);南京农业大学青年科技创新基金(No.KJ06015)资助

摘　　要：将180羽1日龄Arbor Acres(AA)肉鸡随机分为饲料中不添加脱氢表雄酮(DHEA)的对照组,添加20和5mg/kgDHEA的高、低剂量组,饲喂至42日龄时分别从各组随机取12只公鸡和母鸡,采集血样、肝脏、腹脂、左侧胸肌和腿肌,分别测定血清葡萄糖(BG)、甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白(HDL-C)、低密度脂蛋白(LDL-C)、非酯化脂肪酸(NEFA)、三碘甲腺原氨酸(T3)、甲状腺素(T4)、游离三碘甲腺原氨酸(FT3)、游离甲状腺素(FT4)、胰高血糖素(glucagon)和瘦素(leptin)含量。结果表明,与对照组相比,DHEA显著降低肉鸡体重、腹脂重和腹脂率,显著降低TG、TC、HDL-C、FT3和FT4含量,显著升高瘦素含量,而对血糖和LDL-C没有影响;DHEA使公鸡血清NEFA含量升高,母鸡血清NEFA含量降低;DHEA使公鸡血清LPL活性和胰高血糖素含量显著升高,血清T4显著降低。DHEA可能通过提高肉鸡体内脂类分解代谢相关酶的活性及激素水平,对脂类代谢起调节作用。Effect of different dehydroepiandrosterone （DHEA） supplemental levels in Arbor Acres （AA） broiler feed on lipid metabolism and related hormones were studied. One hundred and eighty day-old AA broilers were randomly allocated to three groups, each group included three replicates with 20 broilers. DHEA was not added in the basal feed （control group）. The low DHEA and high DHEA treated groups were fed with the basal feed with the supplementation of 5 and 20 mg/kg from 1 to 42 day-old, respectively. Twelve cocks and hens per group were randomly chosen for blood, liver, abdominal fat, let＇t breast and thigh muscle samples at 42 day-old. The content of blood glucose（BG）, triglycerides （TG）, total cholesterol （TC）, high density lipoprotein- cholesterol （HDL-C）, low density lipoprotein-cholesterol （LDL-C）,non-esterified fatty acid （NEFA）, triiodothyronine（T3）, thyroxin（T4）, flee triiodothyronine （FT3）, free thyroxin（FT4）, glucagon, leptin and the activity of lipoprotein lipase （LPL） were detected. The results showed that the body weight, abdominal fat weight, percentage of abdominal fat weight and TG,TC, HDL-C, FT3 and FT4 were significantly decreased （P〈 0.05） and leptin was significantly increased by DHEA in both gender. The contents of BG and LDL-C were not affected by DHEA. The content of NEFA was obviously elevated in the cocks and decreased in the hens （P〈0.05） by DHEA. The activity of LPL and the content of glucagon in serum were significantly enhanced and T4 was significantly decreased in the cocks （P〈0.05） by DHEA. The results imply that DHEA regulates lipid metabolism of broilers by enhancing the enzyme activity and hormone levels related to lipolysis.

关 键 词：脱氢表雄酮 肉鸡 脂类代谢 激素 

分 类 号：S185[农业科学—农业基础科学]