原发性肝癌合并门静脉癌栓血液动力学变化的MSCTP定量研究  

Study on Multi-slice CT Perfusion of Hemodynamic Change of the Primary Hepatocellular Carcinoma with Portal Vein Tumor Thrombus

作　　者：戚跃勇[1] 邹利光[1] 王细文[1] 孙清荣[1] 郝萍[1] 刘卫金[1] 戴书华[1] 王智平[1] 

机构地区：[1]第三军医大学新桥医院放射科,重庆400037

出　　处：《中国血液流变学杂志》2007年第3期497-500,共4页Chinese Journal of Hemorheology

基　　金：GE公司联合研发基金资助(2004E039)

摘　　要：目的探讨原发性肝癌合并门静脉癌栓血液动力学变化的多层螺旋CT灌注成像(MSCTP)各参数的变化规律。方法应用美国GE公司LightSpeed 16型16层螺旋CT对84例受试对象经右侧肘静脉以4mL/s的速率注射对比剂40mL行MSCT灌注扫描。应用去卷积算法模式计算肝血流量(HBF)、肝血容量(HBV)、平均通过时间(MTT)、毛细血管表面通透性(PS)和肝动脉灌注指数(HAF)等。结果实验A组肿瘤组织的HBF、HAF明显高于阳性对照B组,实验A组PVTT组织的HBV、HAF也明显高于阳性对照B组,而实验A组肿瘤组织的MTT值却短于阳性对照B组。实验A组异常灌注组织的HBF、HBV和HAF值均明显高于阴性对照C组。结论MSCTP灌注参数可定量评价原发性肝癌合并门静脉癌栓血液动力学变化特点。Purpose To study on multi-slice CT perfusion（MSCTP） of hemodynamic change of the primary hepatocellular carcinoma（HCC） with portal vein tumor thrombus（PVTT）.Methods MSCT perfusion imaging was performed with a spiral CT scanner（GE Lightspeed 16 Slice） in total 84 patients and analyzed with perfusion 3 software package.Liver perfusion maps werc calculated by means of the tracer kinetic model.The weighted sum-mation of the aortic and portal venous curve were de-convolved against the liver parenchymal curve to derive functional parameters such as total hepatic blood flow（HBF）,hepatic blood volume（HBV）,mean transit time（MTT）,permeability of capillary vessel surface（PS） and hepatic arterial fraction（HAF） were calculated,and the change of the hemodynamic was estimated.Results Compared with the positive control group B,the HBF and HAF of the tumor in test group A increased significantly,and so the HBV and HAF of the PVTT in test group A（P〈0.05）.However,the MTT of the tumor in test group A was shorter than that of the positive control group B significantly（P 〈0.05）.Compared with the negative control group C,the HBF,HBV and HAF of the hyperperfusion abnormality in test group A increased significantly.Conclusion MSCTP parameters may reflect the features of blood perfusion,and to evaluate the hemodynamic change of HCC with PVTT.

关 键 词：体层摄影术 X线计算机 癌 肝细胞 门静脉 瘤栓 血流灌注 

分 类 号：R814.42[医药卫生—影像医学与核医学] R735.7[医药卫生—放射医学]