DNA甲基化在毒理学中的应用前景  

Perspective and Application of DNA Methylation Evaluation in Toxicology

作　　者：杨建平[1] 朱志良[2] 袁建辉[3] 庄志雄[3] 

机构地区：[1]中山大学 公共卫生学院 预防医学教研室,广东广州510080 [2]深圳市宝安区疾病预防控制中心,广东深圳518101 [3]深圳市疾病预防控制中心,广东深圳518020

出　　处：《环境与职业医学》2007年第5期546-549,共4页Journal of Environmental and Occupational Medicine

基　　金：国家重点基础研究计划(973)项目(编号:2002CB512903);国家自然科学基金(编号:30571592);广东省科委自然科学基金(编号:04002730);深圳市科技计划重点资助项目(编号:JH200505300503A)

摘　　要：许多物理或化学因子具有潜在的对基因组引起不利的遗传变化,导致基因型遗传上的不利改变,通常认为会导致突变的结果。然而,致突变作用并不是遗传改变的唯一机制,表观遗传基础对此也具有重要作用。DNA甲基化成为外遗传的基础机制已经倍受关注。基于甲基化异常与疾病之间的关系及近年毒物对DNA甲基化研究的基础,我们指出DNA甲基化改变在许多化学物毒性中起重要的作用,DNA甲基化状态评价对于全部安全性评价具有重要应用前景。In general, many physical and chemical factors have potential adverse effect on genome which may result in mutation. But, mutagenic action is not the only mechanism of hereditary change, the epigenetic mechanism may also play an important role in it. Based on not only the correlated researches between DNA methylation and disease but also the advance studies of toxic effect of many chemicals on DNA methylation, we point out that DNA methylation evaluation will have wide application and perspective in total safety evaluation for many physical and chemical factors,which might have potential adverse effect on human health.

关 键 词：表观遗传 DNA甲基化 毒理学 

分 类 号：R114[医药卫生—卫生毒理学]