二氧化硅粉尘对肾功能影响及其敏感检测指标的研究  

STUDY ON THE RENAL FUNCTION DAMACE OFWORKERS EXPOSED TO SILICA DUST ANDTHEIR SENSLBL;E INDICES OF EARLY DETECTION

作　　者：徐成伟[1,2,3] 戴秀莲[1,2,3] 孙少秋 邵华 邹先清[1,2,3] 吴红卫 

机构地区：[1]山东医科大学第二附属医院 [2]山东省劳动卫生职业病防治研究所 [3]济南市职业病防治院

出　　处：《山东医科大学学报》1997年第2期132-137,共6页Acta Academiae Medicinae Shandong

摘　　要：为探讨二氧化硅粉尘接触与肾功能的关系，测定了１５３名二氧化硅粉尘接触工人、１１２例矽肺患者及年龄相当的非接尘对照人群的尿酶和尿中微量蛋白的含量。结果表明，接尘工人和矽肺患者尿微球蛋白（α－ＭＧ）、β－微球蛋白（β－ＭＧ）。lan order to find the relations between Nephrotoxicity and exposure to slilica dust , 153 workers exposed to silica dust , 112 silicotic patients and 152 men non-exposed to dust as controls were investigated , and their four kinds of urinary enzymes and five kinds of urinary microglobulins were measured . The results showed that the urinary excretions of a- microglobulin ( a-MG ) ,b-microglobulin ( pa-MG ) , albumin ( Alb ) and N-acetyl-D- glucosaminidase ( NAG ) in the worker. exposed to silica dust and silicotic patients were significantly higher than those in controls. These increases did relate with duration of exposure in both silica dust exposed workers and silicotic patients , but not relate with the duration of de-exposure and degree of silicosis in silicotic patients The conclusion is that exposure to silica dust may lead to chronic irreversible subclinical nephrotoxicity in exposed workers. Measuring urinary a-MC ,-MG , Alb level and NAG activity in urine may be valuable indices for early detection of chronic nephrotoxicity caused by silica dust.

关 键 词：二氧化硅 粉尘 尿 酶类 蛋白质 肾损害 

分 类 号：R135.2[医药卫生—劳动卫生] R692.02[医药卫生—公共卫生与预防医学]