RhoGTPases in stem cells  

作　　者：YAO HaiLei XIE XiaoYan WANG DongMei PEI XueTao 

机构地区：[1]Department of Stem Cells and Regenerative Medicine, Beijing Institute of Transfusion Medicine,Beijing 100850, China

出　　处：《Chinese Science Bulletin》2007年第22期3025-3028,共4页

基　　金：Supported by State 863 High Technology R&D Project of China (Grant No. 2006AA02A107);the National Key Project for Basic Research of China (Grant No. 2005CB522702)

摘　　要：RhoGTPases are small molecules that control a wide variety of signal transduction pathways. Their profound function in regulating the actin cytoskeleton is well recognized. Stem cells are unique in their ability to self-renew and produce progenitor cells that can differentiate into specialized cells. RhoGTPases influence stem cell morphology and cell migration as well as stem cell self-renewal,proliferation,transplantation,homing and differentiation. In this review,the multiple roles of the RhoGTPases in stem cells are discussed.RhoGTPases are small molecules that control a wide variety of signal transduction pathways. Their profound function in regulating the actin cytoskeleton is well recognized. Stem cells are unique in their ability to self-renew and produce progenitor cells that can differentiate into specialized cells. RhoGTPases influence stem cell morphology and cell migration as well as stem cell self-renewal, proliferation, transplantation, homing and differentiation. In this review, the multiple roles of the RhoGTPases in stem cells are discussed.

关 键 词：干细胞 自我更新能力 转换方式 调节作用 

分 类 号：Q25[生物学—细胞生物学]