1-[1-(6-甲氧基-2-萘基)乙基]-2-(4-硝基苄基)-6,7-二甲氧基-1,2,3,4-四氢异喹啉氢溴酸盐的光降解产物研究  

Photo-degradation products of 1-[1-(6-methoxy-2-naphthyl)ethyl]-2-(4-nitrobenzyl)-6,7-dimethoxyl-1,2,3,4-tetrahydroisoquinoline hydrobromide

作　　者：姜红[1] 宋敏[1] 杭太俊[1] 张正行[1] 

机构地区：[1]中国药科大学药物分析教研室,江苏南京210009

出　　处：《药学学报》2007年第10期1078-1081,共4页Acta Pharmaceutica Sinica

基　　金：国家自然科学基金资助项目(30472066).

摘　　要：研究1-[1-(6-甲氧基-2-萘基)乙基]-2-(4-硝基苄基)-6,7-二甲氧基-1,2,3,4-四氢异喹啉氢溴酸盐(编号P91024)遇光后颜色变暗的光降解产物。采用HPLC-MS及波谱分析鉴定光降解产物的化学结构,并经有机反应合成对照验证。P91024光降解的3个主要产物分别为溴化N-(4-硝基苄基)-6,7-二甲氧基-3,4-二氢异喹啉、1-[1-(6-甲氧基-2-萘基)乙基]-6,7-二甲氧基-1,2,3,4-四氢异喹啉和2-异丙基-6-甲氧基萘。To study the photo-degradation products of 1-[ 1-（ 6-methoxy-2-naphthyl ） ethyl ]-2-（ 4- nitrobenzyl） -6,7-dimethoxyl-1 , 2,3,4-tetrahydroisoquinoline hydrobromide （ code designation ： P91024 ）. The chemical structures of the major photo-degradation products of P91024 were identified by HPLC-MS and spectroscopic methods, and their reference substances were also synthesized for confirmation. The three major photo-degradation products were identified to be N-（4-nitrobenzyl）-6,7-dimethoxyl-3,4- dihydroisoquinoline bromide, 1-[ 1-（ 6-methoxyl-2-naphthyl ） ethyl ]-6, 7-dimethoxyl-1, 2, 3, 4- tetrahydroisoquinoline and 2-isopropyl-6- methoxyl-naphthalene, respectively.

关 键 词：1-[1-(6-甲氧基-2-萘基)乙基]-2-(4-硝基苄基)-6 7-二甲氧基-1 2 3 4-四氢异喹啉氢溴酸盐 光降解产物 结构鉴定 

分 类 号：R917[医药卫生—药物分析学]