焦磷酸二甲基烯丙酯及其异构物和衍生物的合成  

Synthesis of Dimethylallyl Pyrophosphate and its Isomer and Derivatives

作　　者：田原[1] 韩佩珍[1] 田淑浩[1] 

机构地区：[1]中国医学科学院中国协和医科大学放射医学研究所

出　　处：《中国药物化学杂志》1997年第2期140-142,148,共4页Chinese Journal of Medicinal Chemistry

摘　　要：报道了两步合成焦磷酸烯丙酯的方法，以醇为原料制备相应的对甲苯磺酸酯、溴化物或氯化物，然后与焦磷酸氢－三（四－正丁铵）进行焦磷酸化，合成了５种焦磷酸烯丙酯，产品经薄层色谱。A two step procedure for synthesis of allylic pyrophosphate esters was used,it involved treatment of the alcohols via the corresponding intermediate compounds such as p toluene sulfonate,bromide or chloride,and then pyrophosphorylation with tris(tetra n butyl amonium)hydrogen pyrophosphate.Five allylic pyrophosphate esters were synthesized.The products,as judged by TLC and 1H, 31 P NMR,are proved to be free of contaminants.

关 键 词：药物中间体 焦磷酸 二甲基烯丙酯 合成 

分 类 号：TQ460.4[化学工程—制药化工]