补充不同钙量对低钙膳食大鼠血钙及生长的影响  

EFFECT OF LOW Ca DIET SUPPLEMENTED WITH VARIOUS Ca AMOUNTS ON SERUM Ca AND GROWTH IN RATS

作　　者：郭成浩[1,2] 孙波[1,2] 盖丽云[1,2] 康德仁[1,2] 王凡[1,2] 李广生[1,2] 

机构地区：[1]白求恩医科大学地方病研究所 [2]青岛大学医学院中心实验室

出　　处：《营养学报》1997年第1期50-52,共3页Acta Nutrimenta Sinica

基　　金：自然科学基金

摘　　要：报告了低Ｃａ（ＬＣ），补充钙（ｍｇ／ｋｇ）３００（ＬＣ＋３００Ｃａ）、６００（ＬＣ＋６００Ｃａ）、１０００（ＬＣ＋１０００Ｃａ）、２０００（ＬＣ＋２０００Ｃａ）、４０００（ＬＣ＋４０００Ｃａ）对低钙膳食大鼠血钙及生长的影响。结果表明，低钙膳食（ＬＣ）喂养大鼠血钙、总蛋白（ＴＰ）及生长激素（ＧＨ）水平较低，生长迟缓，明显低于常规食组。补充不同水平的钙均可改善大鼠上述状态，呈明显的量效关系。当膳食内总钙水平达１０００ｍｇ／ｋｇ左右时，即ＬＣ＋６００ｍｇ／ｋｇ组，血钙水平接近正常；ＧＨ分泌增加、ＴＰ增加，与ＬＣ组比差异显著。说明低钙对喂养大鼠所造成的生长迟缓起重要作用。当膳食内总钙至１０００ｍｇ／ｋｇ时，可改善生长状态及代谢编移。The effects of supplemented various levels of Ca on serum Ca and growth of rats fed endemic monotonous diet containing low Ca(LC) were studied. The results showed that serum Ca,growth hormone(GH)levels,pituitary GH cell numbers and secretion pellet in LC group were lower than the others.When LC diet was supplemented various levels Ca,all above changes could be improved,and there was a significant dose- response relationship between diet Ca and serum Ca,total protein(TP),GH levels.When diet total Ca was up to 1000mg/kg(LC+600Ca group),serum Ca was close to normal,GH secretion increased and TP elevated,they were markedly different from LC group.The study demonstrated that low Ca diet played an important role on growth retardation of rats fed LC diet.When total Ca in diet was up to 1000mg/kg, growth and metabolic deviation could be improved.

关 键 词：膳食低钙 血钙 生长 生长激素 克山病 

分 类 号：R542.3[医药卫生—心血管疾病] R151.3[医药卫生—内科学]