野生马齿苋抗动脉粥样硬化形成的实验研究  

THE EFFECT OF WILD PURSLANE ON ATHEROSCLEROSIS IN RABBITS

作　　者：贺圣文[1] 范志涛[1] 李佩贤[1] 吕士军 韩连堂[1] 洪舜华[1] 

机构地区：[1]潍坊医学院卫生学教研室潍坊医学院病理解剖教研室

出　　处：《营养学报》1997年第1期59-63,共5页Acta Nutrimenta Sinica

摘　　要：用野生马齿苋饲高脂膳食家兔作为实验性高脂血症和动脉粥样硬化（ＡＳ）的预防实验。通过血脂、血粘度及透射电镜下主动脉内膜超微结构的变化，探讨其作用机理。结果表明：１．野生马齿苋明显降低血清总胆固醇（ＴＣ），甘油三脂（ＴＧ）及低密度脂蛋白胆固醇（ＬＤＬ－Ｃ），升高血清高密度脂蛋白胆固醇（ＨＤＬ－Ｃ）。２．野生马齿苋可降低全血低切表观粘度，可明显降低血浆中切表观粘度，对全血中切表观粘度也有降低趋势。３．电镜观察显示野生马齿苋能有效地减轻主动脉壁脂质沉积，并有抑制动脉粥样硬化斑块形成的作用。The effects of wild purslane on serum lipids,blood viscosity and atherosclerosis were investigated in rabbits.Each animal was given eight gram wild purslane/day for 11 weeks.The results showed:1.Purslane could markedly decrease serum TC、TG and LDL C concentration,but obviously increase HDL C concentration. There were significant differences compared to the positive control group.2.Purslane could effectively lower plasma middle shearing viscosity and whole blood low shearing viscosity,it also showed a tendency to lower the levels of whole blood middle shearing viscosity,but it did not reach a statistical significance.3.It was proved under the observation of electron microscope that purslane could lower lipids deposition of aorta intima and inhibit the formation of atherosclerotic plaque.

关 键 词：马齿苋 血脂 血液粘度 泡沫细胞 动脉粥样硬化 

分 类 号：R543.5[医药卫生—心血管疾病] R151.2[医药卫生—内科学]