1-(2,3,4,6-四-O-特戊酰基-β-D-吡喃葡萄糖基)-4-苯基-1,2,3-三氮唑的合成  

Synthesis of 1-(2,3,4,6-Tetra-O-pivaloyl-β-D-glucopyranosyl)-4-phenyl-1,2,3-triazole

作　　者：周国斌[1] 管月清[1] 刘晓明[1] 王倩[1] 陈慧宗[2] 

机构地区：[1]山东科技大学化学与环境工程学院,山东青岛266510 [2]江西师范大学化学化工学院,江西南昌330027

出　　处：《山东科技大学学报（自然科学版）》2007年第4期51-53,共3页Journal of Shandong University of Science and Technology(Natural Science)

基　　金：国家自然科学基金(20662005)

摘　　要：开展了2,3,4,6-四-O-特戊酰基-β-D-吡喃葡萄糖叠氮与炔烃的1,3-偶极环加成反应的研究,并首次合成了一种新的1-(2,3,4,6-四-O-特戊酰基-β-D-吡喃葡萄糖基)-4-苯基-1,2,3-三氮唑,产物经质谱、核磁共振谱及红外光谱进行了结构表征。糖基三氮唑及其衍生物是一类具有重要生物活性的杂环化合物和重要的有机合成中间体,该化合物将在合成N-未取代的具有潜在药理活性的三氮唑类化合物中具有广阔的应用前景。The 1, 3-dipolar eycloaddition reaction of 2, 3, 4, 6-Tetra-O-pivaloyl-13-D-glucopyranosyI azide with 1-ethynylbenzene was studied. The 1-（2, 3, 4, 6-Tetra-O-pivaloyl-β-D-glucopyranosyl）-4-phenyI -1, 2, 3-triazole was synthesized and characterized by MS, NMR, IR first time in the paper. Triazole-linked glycoconjugates and their derivatives are important heterocyclic compounds with biological activity and organic intermediate which could serve as the important intermediates for the synthesis of N-unsubstituted t, 2,3-triazoles.

关 键 词：1 2 3-三氮唑 葡萄糖 1-(2 3 4 6-四-O-特戊酰基-β-D-吡喃葡萄糖基)-4-苯基-1 2 3-三氮唑 合成 

分 类 号：O621.3[理学—有机化学]