微波合成1-对羟基苄基-2-对羟基苯基苯并咪唑  

Synthesis of 1-(p-hydroxybenzyl)-2-(p-hydroxyphenzyl)-benzimidazole under microwave irradiation

作　　者：吕维忠[1] 刘波[1] 韦少慧[1] 吴奕光[1] 刘剑洪[1] 

机构地区：[1]深圳大学化学与化工学院,深圳518060

出　　处：《深圳大学学报（理工版）》2007年第4期432-435,共4页Journal of Shenzhen University(Science and Engineering)

摘　　要：在微波辐射下,用乙醇作溶剂,以邻苯二胺和对羟基苯甲醛为原料,合成了对1-羟基苄基-2-对羟基苯基苯并咪唑.利用正交法优化微波促进该反应的工艺条件,优化工艺参数,选n(对羟基苯甲醛):n(邻苯二胺)为2.3∶1.0,微波辐射温度为78℃,微波辐射时间为60min,产率达69.7%.用IR、1HNMR和13CNMR对产物进行了表征.1 - （p-hydroxybenzyl） -2- （p-hydroxyphenzyl） -benzimidazole was synthesized by the reaction of o-phenylenediamine with p-hydroxybenaldehyde. The reaction was accelerated by microwave irradiation with ethyl alcohol as solvent. The method of orthogonal experiment optimized synthesis factors which affect the reaction. The reaction parameters are n （p-hydroxybenaldehyde）： n （o-phenylenediamine） = 2.3： 1.0, and the temperature of microwave irradiation 78℃ , the time of microwave irradiation 60rain. The highest yield of the title compound was 69.7%. The samples synthesized were characterized by melting point determination, IR spectrogram, ^1HNMR spectra and ^13 CNMR spectra.

关 键 词：微波辐射 邻苯二胺 对羟基苯甲醛 苯并咪唑 

分 类 号：O626.25[理学—有机化学]