普通肝素的2种不同给药途径在血液透析中用量的观察  

Comparison of heparin dosage administered by two methods for hemodialysis

作　　者：申志祥[1] 陈培培[1] 张悦[1] 

机构地区：[1]江苏省老年医院,南京210024

出　　处：《中国血液净化》2007年第11期590-592,共3页Chinese Journal of Blood Purification

摘　　要：目的采用2种不同的首量肝素给药途径进行抗凝,比较两者在血液透析中抗凝效果及所用肝素总量。方法选择江苏省老年医院血液净化中心64例维持性血液透析患者,先采用常规普通肝素抗凝法(静脉组)。其后改为首量肝素动脉端给药抗凝法(动脉组),根据透析器凝血等级调整肝素用量,直至凝血等级稳定在0级或1级。分别记录2种给药途径所用肝素首量和总量及凝血等级。结果动脉组首量肝素及肝素总量较静脉组有显著的优越性(P<0.05);动脉组凝血等级0级由16例增加36例(x2=15.14,P<0.01)。64例患者无1例出现透析器凝血等级增加。结论动脉组肝素给药途径能够显著减少肝素使用量,临床应用安全性良好。Objective To investigate the anticoagulation effect and the dosage of heparin administered by two ways in hemdialysis. Methods Sixty-four patients were enrolled in this study. The patients first received heparin by conventional administration method for anticoagulation in hemodialysis （intravenous group）, then they were given the initial heparin by intra-arterial way （intra-arterial group）. The initial dose, total dose of heparin and the coagulation grade of the two groups were recorded. Results The initial dose and total dose of heparin were significantly different between the two groups. The anticoagulation effect was grade 0 in 36 patients in the intra-arterial group, but in 16 cases in the intravenous group. Conclusion Intra-arterial administration of heparin in hemodialysis significantly reduces the dosage of heparin with satisfactory safety.

关 键 词：肝素 血液透析 动脉给药 

分 类 号：R973[医药卫生—药品] R318.16[医药卫生—药学]