血浆置换治疗对重型肝炎患者凝血及纤溶指标的影响  

Plasmapheresis on coagulation and fibrinolysis functions in severe chronic hepatitis patients

作　　者：欧强[1] 王渭康[1] 殷科珊[1] 盛燕[1] 

机构地区：[1]复旦大学附属公共卫生临床中心血液净化室,上海201508

出　　处：《中国血液净化》2007年第11期608-609,共2页Chinese Journal of Blood Purification

摘　　要：目的探讨血浆置换(PE)治疗对慢性重型肝炎患者凝血及纤溶指标的影响。方法选择复旦大学附属公共卫生临床中心血液净化室20例慢性重型肝炎患者进行65例次PE治疗,观察治疗前后凝血和纤溶指标的变化情况。结果20例患者经PE治疗后,临床症状均有不同程度的改善。PE治疗后凝血酶原时间(PT)、部分活化凝血时间(KPTT)、国际标准化比率(INR)、纤维蛋白原(FIB)、纤维蛋白降解产物(FDP)较治疗前明显减少,而凝血酶原活动度(PTA)、凝血Ⅴ因子、凝血Ⅶ因子较治疗前明显增高,差异有显著性(P<0.05)。结论PE能有效改善慢性重型肝炎患者凝血及纤溶功能。Objective To investigate plasmapheresis on coagulation and fibrinolysis in severe chronic hepatitis patients. Methods Twenty patients with severe chronic hepatitis received plasmapheresis in a total of 65 times. We observed the changes of coagulation and fibrinolysis in these patients before and after the plasmapheresis treatment. Results After the treatment, clinical symptoms improved in all patients. Prothrombin time, kaolin partial thromboplastin time （KPTT）, international normalized ratio （INR）, fibrinogen and fibrinogen degradation products （FDP） decreased. Plasma thromboplastin antecedent （PTA）, coagulation factors Ⅴ and Ⅶ increased （P 〈0.05 or 0.01）. Conclusion Plasmapheresis is effective to improve the coagulation and fibrinolysis functions in patients with severe chronic hepatitis.

关 键 词：人工肝 慢性重型肝炎 凝血 纤溶 

分 类 号：R318.14[医药卫生—生物医学工程]