血管紧张素Ⅱ对兔急性心肌梗死心律失常的影响  

The effect of angiotensin Ⅱ on arrhythmia of acute myocardial infarction in rabbits

作　　者：刘鹰[1] 闭肇龙[1] 唐耀平[1] 梁坚坚[1] 叶慧恒[1] 

机构地区：[1]广西中医学院附属瑞康医院心电图科,南宁530011

出　　处：《中华老年心脑血管病杂志》2007年第11期769-770,共2页Chinese Journal of Geriatric Heart,Brain and Vessel Diseases

摘　　要：目的研究血管紧张素Ⅱ(AngⅡ)与急性心肌梗死心律失常的关系。方法将30只新西兰大白兔随机分为对照组、梗死组和梗死加卡托普利组,采用结扎冠状动脉左前降支方法制作急性心肌梗死模型,于结扎前和结扎后40min分别检测AngⅡ的含量,并记录室性期前收缩、室性心动过速、心室颤动发生率。结果结扎前各组AngⅡ含量差异无显著性意义(P>0.05),也未发生明显的心律失常;结扎后40min对照组AngⅡ含量基本不变,也未发生明显的心律失常,梗死组和梗死加卡托普利组AngⅡ含量明显升高,均发生明显的心律失常(P<0.01),梗死组的AngⅡ含量最高,心律失常发生率也较梗死加卡托普利组高(P<0.05)。结论急性心肌梗死时AngⅡ增高,可能是导致急性心肌梗死心律失常发生的重要因素之一。Objective To study the relationship between angiotensin Ⅱ（Ang Ⅱ）and the arrhythmia of acute myocardial infarction（AMI）. Methods A total of 30 New Zealand white rabbits were divided into control group,AMI group and AMI＋ captopril group. The models of AMI were made by ligating the left anterior descending coronary artery. The Ang Ⅱ content and the incidence rates of the premature ventricualr conlraction,ventricular tachycardia and ventricular fibrillation were recorded before and after 40 minutes of experiment. Results The Ang Ⅱ levels of all groups had no obvious difference（ P 〉0.05） and no obvious arhythmia was found before experiment. Forty minutes after ligating the coronary artery, no change of the Ang Ⅱ level was found and no arrhythmia occurred in control group. In AMI group and AMI＋ captopril group,the Ang Ⅱ levels rose obviously and the rates of arrhythmia significantly increased（ P 〈0.01）too. The Ang Ⅱ content of AMI group was highest and the incidence of arrhythmia was higher than that of AMI＋ captopril group （ P 〈0.05）. Conclusion The Ang Ⅱ level will increase when the patients get AMI. This may be one of the important factors leading to arrhythmia.

关 键 词：心肌梗塞 心律失常 血管紧张素Ⅱ 卡托普利 

分 类 号：R542.22[医药卫生—心血管疾病]