基于计算流体力学的小血管生物反应器设计  

Design of small blood vessel bioreactor based on computational fluid dynamics

作　　者：李宏[1,2] 安琦[2] 曹珲[1] 余毅勤 崔磊[1] 刘伟[1] 曹谊林[1] 

机构地区：[1]上海组织工程研究与开发中心,200235 [2]华东理工大学,上海200237

出　　处：《国际生物医学工程杂志》2007年第5期261-264,共4页International Journal of Biomedical Engineering

基　　金：国家“973”计划资助项目（G1999054300）

摘　　要：目的：设计一套能构建内壁直径为2mm的组织工程小血管的生物反应器。方法：根据计算流体力学原理和方法对组织工程小血管托架材料进行分析，设计一套用于培养2mm小血管的生物反应器。采用压注成型技术制作了小血管的托架。结果：确定了硅胶管的尺寸结构并获得了成型产品，设计完成了培养室内相应的辅助结构，使整个反应器系统能够对PGA-细胞材料复合物进行动态培养。结论：小血管托架的流体力学仿真分析是合理的，在此基础上构建的血管生物反应器性能稳定、可靠。Objective Design a set of bioreactor for tissue-engineered small blood vessel of 2 mm inner wall diameter. Methods Analysis on scaffold for tissue-engineered small blood vessel was carried out using the principle and methods of computational fluid dynamics （CFD）. A set of bioreactor for 2 mm inner wall diameter blood vessel was designed and scaffold of small blood vessel was produced using the die-casting modeling method. Results The dimension and structure of the silica gel vessel was confirmed and finished product was obtained. The design of the corresponding assistant structure inside the culture chamber was completed so that PGA based cell-scaffold composite can be cultured dynamically in the bioreactor system. Conclusion The simulation analysis of hydromechanics made on the scaffold of small blood vessel is practical and reliability of the blood vessel bioreactor based on this was confirmed.

关 键 词：组织工程 血管生物反应器 计算流体力学 

分 类 号：R3[医药卫生—基础医学]