BMP-4对胚胎鼠肺发育的影响  

Influence of BMP-4 on embryonic mouse lung development

作　　者：谭文斐[1] 王俊科[1] 

机构地区：[1]中国医科大学附属第一医院麻醉科,沈阳110001

出　　处：《国际麻醉学与复苏杂志》2007年第5期438-440,共3页International Journal of Anesthesiology and Resuscitation

摘　　要：骨形态构建蛋白(BMPs)控制着细胞的分裂、增殖。BMP-4在胚胎鼠肺发育过程中必不可少。在早期支气管形态构建过程中,可以观察到BMP-4动态的表达。BMP家族其他成员的临床意义显著,提示我们BMP-4对于成年鼠肺损伤保护作用值得深入的研究探索。Members of transforming growth factor （TGF）-β family play central roles in controlling cellular proliferation, differentiation and survival. TGF-β family is divided into three subgroups, among which bone morphogenetic proteins （BMPs） constitutes the largest subfamily. BMP-4, one of BMPs, is involved in embryonic mouse lung development. During early process of bronchia morphogenesis, dynamic expression of BMP-4 occurs. Even though BMP-4 is involved in lung development, its protective role during lung injury in adult mouse has not been investigated so far.

关 键 词：骨形态构建蛋白 肺发育 胚胎鼠 BMP-4 肺损伤 保护作用 

分 类 号：R563[医药卫生—呼吸系统]