吸入麻醉药心肌预处理的信号转导机制  

Signal transduction of inhalation anesthetic preconditioning

作　　者：王耀岐[1] 曾因明[2] 

机构地区：[1]山东滨州医学院附属医院麻醉科,256603 [2]江苏省麻醉医学研究所,徐州医学院江苏省麻醉学重点实验室

出　　处：《国际麻醉学与复苏杂志》2007年第5期445-448,共4页International Journal of Anesthesiology and Resuscitation

摘　　要：吸入麻醉药预处理有IPC样的心肌保护作用,其作用机制目前尚未完全阐明。吸入麻醉药预处理的信号转导机制可能与IPC的信号转导途径相似,吸入麻醉药可能刺激心肌产生触发因子,然后启动级联反应,激活效应因子,发挥预处理效应。目前为止,研究已证实ROS、G蛋白耦联受体、蛋白激酶、线粒体和肌膜K_(ATP)通道(Mito K_(ATP) and Sarc K_(ATP))介导APC。现就吸入麻醉药心肌预处理信号转导机制方面的最新进展作一综述。Inhalation anesthetic preconditioning （APC） has similar effect to ischemic preconditioning （IPC） which protects myocardium against ischemic/reperfusion injury. But it＇ s mechanism has not been fully understood. The signal transduction of APC may similar to that of IPC. Inhalation anesthetics may stimulate myocardium to produce triggers which initiate cascade reactions, and then activate effectors in the end. Up to now, it has been confirmed that ROS, G protein - coupled receptors, protein kinases and KATP channel are involved in APC. The latest advance in signal transduction of APC is reviewed in this article.

关 键 词：吸入麻醉药 心肌预处理 信号转导 

分 类 号：R96[医药卫生—药理学]