聚乳酸/壳聚糖互穿网络薄膜的合成及药物释放  

Synthesis and drug release behavior of polylactide/chitosan IPN film

作　　者：杨华[1] 蒋林斌[1] 黄爱民[1] 邓先模[2] 

机构地区：[1]广西大学化学与化工学院,广西南宁530004 [2]中科院成都有机化学研究所,四川成都610041

出　　处：《暨南大学学报（自然科学与医学版）》2007年第5期494-497,共4页Journal of Jinan University(Natural Science & Medicine Edition)

摘　　要：利用丙烯酰化的低分子质量聚乳酸和壳聚糖形成互穿网络(IPN)结构的薄膜.实验显示改变壳聚糖与聚乳酸比例及聚乳酸分子质量,能调控薄膜的溶胀速率和降解行为.以人血清蛋白作为模型药物,初步表明此类材料可以用做药物释放载体.可见聚乳酸/壳聚糖IPN薄膜具有pH敏感性和两亲性,有望应用于蛋白类药物的控制释放.To synthesize drug carriers for controlled release. Interpenetrating network （IPN） films were prepared by acrylated polylactide （PLA） with low molecule weight and chitosan. Swelling rate and degradation could be adjusted by changing the molecule weight of PLA and the ratio of chitosan to PLA. The release of human serum albumin （HSA） showed that the IPN film could be used to drug carrier. The IPN film possessed pH sensitivity and amphiphilicity, could be applied in protein drug controlled release.

关 键 词：互穿网络 丙烯酰化的聚乳酸 壳聚糖 溶胀速率 释放速率 

分 类 号：O631[理学—高分子化学]