己酮可可碱结肠定位包衣片制备工艺研究  

Preparation of pentoxifylline enteric-coated tablets for targeting drugs on the colon

作　　者：吴杏梅[1] 

机构地区：[1]佛山市第一人民医院药剂科,广东佛山528000

出　　处：《广东药学院学报》2007年第5期525-527,共3页Academic Journal of Guangdong College of Pharmacy

摘　　要：目的制备己酮可可碱结肠定位包衣片。方法制备己酮可可碱片芯,以药物体外释放50%所需要的时间为指标,采用正交试验优选包衣片的最佳处方。结果最佳包衣处方:缓释层成分组成Eudragit RL∶RS质量比为1∶1.5,缓释层包衣增重为2.0%,肠溶层包衣增重为6%,固化时间是3 h。结论己酮可可碱结肠定位包衣片制备工艺简单、合理可行。Objective To prepare the pentoxifylline enteric-coated tablets for targeting drugs on the colon. Methods The core tablets were prepared and orthogonal design was used to optimize the coating formulation. Results Eudragit RL-RS （1：1.5 ）, 2.0% weight increase of the sustained-release layer,6% weight increase of the enteric layer,3 h of the setting time were the optimized coating formulations. Conclusion The preparation procedure of pentoxifylline enteric-coated tablets was simple and practical.

关 键 词：己酮可可碱 结肠定位包衣片 体外释药 

分 类 号：TQ463[化学工程—制药化工]