石榴皮对红细胞膜脂质过氧化的保护作用  

The protective effect of pomegranate pericarps(Punica granatum L.) on erythrocyte membrane lipid peroxidation

作　　者：周本宏[1] 王慧媛[2] 吴玥[2] 冯琪[2] 刘春[2] 张杰[1] 

机构地区：[1]武汉大学人民医院药学部,湖北武汉430060 [2]武汉大学药学院,湖北武汉430072

出　　处：《广东药学院学报》2007年第5期547-549,共3页Academic Journal of Guangdong College of Pharmacy

基　　金：国家自然科学基金资助项目(30370157)

摘　　要：目的研究石榴(Punica granatum L.)皮提取物对红细胞膜脂质过氧化损伤的保护作用。方法采用3种活性氧产生体系诱发脂质过氧化为实验模型,设立模型对照组(MC)、正常对照组(NC)以及3个石榴皮提取物给药组,观察比较各组的丙二醛(MDA)含量。结果同MC组相比,三组石榴皮提取物对黄嘌呤-黄嘌呤氧化酶系统、H2O2及UV照射3种方法引起的细胞膜脂质过氧化产物丙二醛(MDA)的生成增加均有抑制作用,且有一定的剂量依赖关系。结论石榴皮对自由基引起的细胞膜脂质过氧化损伤有保护作用。Objective To investigate the protective effect of pomegranate pericarps （ Punica granatum L. ） on lipid peroxidation damage of erythrocyte membrane. Methods Model of lipid peroxidation of erythrocyte membrane was made by three kinds of radicals generation systems, xanthine（Xan）-xanthine oxidase（XO） system, H： O：, and UV light. Observation was made on the content of malondialdehyde （MDA）. Results Compared with MC group, the increases of MDA content in the membrane induced by Xan-XO system, H2O2 or UV light in all of the three Punica granatum L. group were inhibited dose-dependently. Conclusion Punica granatum L. may protect erythrocyte membrane from the lipid peroxidative damage induced by radicals.

关 键 词：石榴 红细胞膜 脂质过氧化 

分 类 号：R285[医药卫生—中药学]