PRA在肾脏移植中的应用  

PRA in renal transplantation

作　　者：肖露露[1,2,3,4,5,6,7,8] 张升[1,2,3,4,5,6,7,8] 叶欣[1,2,3,4,5,6,7,8] 马琳雅[1,2,3,4,5,6,7,8] 陈洪涛[1,2,3,4,5,6,7,8] 郑克立[1,2,3,4,5,6,7,8] 张仕光[1,2,3,4,5,6,7,8] 朱兰英[1,2,3,4,5,6,7,8] 王长希[1,2,3,4,5,6,7,8] 吴培根[1,2,3,4,5,6,7,8] 李希杰[1,2,3,4,5,6,7,8] 高伟 许健宁[1,2,3,4,5,6,7,8] 叶林辉[1,2,3,4,5,6,7,8] 黄湖辉[1,2,3,4,5,6,7,8] 沈昌理[1,2,3,4,5,6,7,8] 肖友光[1,2,3,4,5,6,7,8] 谭尚恒[1,2,3,4,5,6,7,8] 于立新[1,2,3,4,5,6,7,8] 

机构地区：[1]广州器官移植配型中心 [2]中山医科大学第一附属医院器官移植中心 [3]第一军医大学珠江医院透析移植中心 [4]广东省人民医院泌尿外科 [5]中山医科大学孙逸仙纪念医院泌尿外科 [6]武警广东总队医院泌尿外科 [7]广州军区总医院泌尿外科 [8]第一军医大学南方医院泌尿外科

出　　处：《中华泌尿外科杂志》1997年第6期337-340,共4页Chinese Journal of Urology

摘　　要：为深入了解移植免疫生物学反应，对广东地区２５７２例肾移植患者术前进行群体反应性抗体（ＰＲＡ）检测及移植后发生严重排斥反应等指标的观察，以研究ＰＲＡ对肾脏移植的影响。研究证实：ＰＲＡ介导超急性排斥反应，承担移植物早期丧失的责任。移植、妊娠和输血等致敏过程可刺激机体产生ＰＲＡ，ＰＲＡ＞５０％与发生超急等严重排斥反应密切关联，对肾移植构成威胁，认为ＰＲＡ分析应列入组织配型程序。Panel reactive antibody (PRA)was detected before kidney transplantation in 2 572 cases in Guangdong province of China.The result showed hyperactive reaction after kidney transplantation was mediated through PRA leading to the loss of allograft in the early stage.A past history of transplantation,pregnancy or blood transfusion might cause the production of PRA.PRA level higher than 50% would be correlated with hyperactive rejection resulting in the loss of the allograft.So,PRA detection before kidney transplantation is recommended in tissue typing protocol for kidney transplantation.

关 键 词：肾移植 抗原 免疫反应 群体反应性抗体 

分 类 号：R699.203[医药卫生—泌尿科学] 1[医药卫生—外科学]