山丘型地区人群血吸虫再感染前瞻性研究  

Prospective cohort study on human reinfection with Schistosoma japonicum in different seasons within a year in a hilly rural community

作　　者：强广翔 邓玉军 沈福喜 任金根 贝康林 赵久堂 

机构地区：[1]南陵县血吸虫病防治站,安徽南陵县242400

出　　处：《热带病与寄生虫学》2006年第3期153-155,共3页Journal of Tropical Diseases and Parasitology

摘　　要：目的了解山丘型自流灌溉地区人群血吸虫再感染的规律与流行因素,为控制病情、制定相应防治措施提供依据。方法选择安徽省南陵县一灌区中度血吸虫病流行村作为观察试区,追踪观察92例感染者中,经吡喹酮治疗后虫卵转为阴性的76人在一个感染季节内的再感染情况。结果日本血吸虫病患者化疗后经过一个完整的传播季节,其再感染率高达26.3%,超过化疗前人群感染水平。其中,春季和夏季的再感染率均为5.8%;秋季再感染率为16.4%,差异有显著意义(χ2=6.301,P=0.0428)。不同季节人群接触疫水频率无显著差异(χ2=2.694,P=0.8461),生活性接触疫水方式占47.8%、生产性占45.1%、娱乐性占7.1%。结论该地人群再感染秋季最高,尤其好发于男性、青少年。本研究为当地制订预防血吸虫再感染的措施提供了理论依据。　Objective To study human reinfection with Schistosoma japonicum and its risk factors after chemotherapy in a middle endemic village with an irrigation canal system in a hilly rural community. Methods A total of 76 individuals in a hilly endemic area in Nanling County, Anhui Province, who were rendered Schistosoma japonicum egg negative by praziquantel treatment, were taken as reinfection study population. Stool examination （egg hatching test） for identification of reinfection and investigation of factors related to reinfection were performed in the whole transmission season. Results One year after treatment, the prevalence of reinfection in the middle endemic village was 26.3% , returning to more than the initial prevalence, with 5.8% in Spring, 5.8% in summer and 16.4% in fall. There was a significant difference for the prevalence of reinfection in different season （χ2=6.301,P=0.0428）. However, no significant difference was found for the rate of water exposure in every month from Apr. to Oct （χ2=2.694,P=0.8461）. The main ways of water exposure are production activity （47.8%）, life activity （45.1%） and entertainment （7.1%）. Conclusion reinfection was more likely to happen in fall in male, especially for children. These findings may form a basis for improving human ability against schistosome reinfection and taking suitable strategy to prevent human reinfection with Schistosoma japonicum in these reigions.

关 键 词：日本血吸虫 再感染 危险因素 

分 类 号：R532.21[医药卫生—内科学]