糖肾通络方对早期糖尿病肾病患者血清内皮素、心钠素的影响  

Effect of Tangshen Tongluo Recipe on Serum ET and ANP in Patients with Early Diabetic Nephropathy

作　　者：徐丽梅[1] 马建伟[1] 支艳[1] 马新英[1] 胡海翔[1] 魏汉林[1] 张文龙[1] 陈宝[1] 侯杰[1] 

机构地区：[1]中国人民解放军空军总医院中医科,北京100036

出　　处：《中国中医药信息杂志》2007年第11期13-15,共3页Chinese Journal of Information on Traditional Chinese Medicine

摘　　要：目的探讨糖肾通络方治疗糖尿病肾病(DN)的疗效及机理。方法45例DN患者随机分为糖肾通络方组(25例)及络丁新组(20例),采用中医证候积分法观察2组治疗前后的积分,采用放射免疫法检测2组治疗前后血中的内皮素(ET)、心钠素(ANP)含量,采用生化法检测血中空腹血糖(FBG)、糖化血红蛋白(HbA1c)、胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)含量及尿蛋白排泄率(UAER)。结果2组治疗后中医证候积分糖肾通络方组明显低于络丁新组(P<0.01),临床总有效率糖肾通络方组明显优于络丁新组(P<0.05),虽然2组患者血中ET、ANP和FBG、HbA1c及UAER均较治疗前明显下降(P<0.05,P<0.01),但糖肾通络方组下降明显优于络丁新组(P<0.05,P<0.01),治疗后糖肾通络方组的TC、TG、LDL-C下降,HDL-C升高较络丁新组明显(P<0.05,P<0.01)。结论糖肾通络方具有较好的调整血脂、血糖,尤其是改善全身症状、提高生活质量的作用,并且能够减低或阻止ANP、ET的产生和分泌,改善肾脏受损的微血管,促进肾小球硬化的修复,达到改善肾功能的目的。Objective To explore effect of the Tangshen Tongluo （TSTL） recipe on ET and ANP in patients with early diabetic nephropathy （DN）. Methods 45 Cases of early DN patients were randomly divided into the TSTL recipe group （25 cases） and Lotensin group （20 cases）. After the treatment of TSTL recipe and Lotensin, TCM symptom, the level of FBG, HbAlc, ET, ANP, TC, TG, HDL-C, LDL-C and urine micro albumen excretion rate （UAER） were detected. Results After the treatment of TSTL recipe and Lotensin, TCM symptom, the level of FBG, ET, ANP, TC, TG, LDL-C and UAER were found markedly lower in the TSTL recipe than that in the Lotensin group （P 〈0.05, P 〈0.01）, and the level of HDL-C was found markedly increased than that in the Lotensin group （P〈0.01）. The total effective rate in the TSTL recipe group was 84.00%, which was higher than that in the Lotensin group （50.00%）, showing significant difference statistically （P〈0.05）. Conclusion TSTL recipe has functions of regulating lipid metabolism and blood glucose, reduce the levels of ET, ANP and UAER, improving main clinical symptoms and quality of life, thus can markedly improve renal function.

关 键 词：糖肾通络方 糖尿病肾病 内皮素 心钠素 尿白蛋白排泄率:肾功能 

分 类 号：R259.872[医药卫生—中西医结合]