经皮冠状动脉介入治疗前后β-血小板球蛋白浓度变化研究  

The Clinical Study on the Concentration of β-TG in Patients with Coronary Heart Disease Treated with Percutaneous Coronary Intervention

作　　者：丁发明[1] 徐丹[1] 张新丽 

机构地区：[1]青岛大学医学院第二附属医院,山东青岛266042 [2]山东省青岛市黄岛区第一人民医院,山东青岛266555

出　　处：《河北医学》2007年第10期1148-1151,共4页Hebei Medicine

摘　　要：目的:探讨经皮冠状动脉介入治疗(PCI)前后β-血小板球蛋白(β-TG)浓度变化及其临床意义。方法:87例行PCI的患者分为不稳定型心绞痛组(40例)和稳定型心绞痛组(47例)。对照组35例为冠状动脉造影正常患者。ELISA法测定β-血小板球蛋白(β-TG)浓度。结果:β-血小板球蛋白(β-TG)浓度水平在PCI术后即刻较术前下降,随后逐渐升高,术后6h达到峰值。不稳定型心绞痛组β-血小板球蛋白(β-TG)浓度在术前及峰值水平均较稳定型心绞痛组升高。对照组患者β-血小板球蛋白(β-TG)浓度在冠状动脉造影前后无显著性变化。结论:血小板激活状态与斑块稳定性密切相关,血小板活性在PCI前后有动态改变,与PCI术后心肌损伤相关。Objective： To study the state of PLT activation in patients with coronary heart disease （CHD） , who were treated with percutaneous coronary intervention （PCI）. The assessment of PLT activation was based on the concentration of β-TG as serum markers of the activation. Method：The study group consisted of 40 patients with unstable angina and 47 patients with stable angina pectoris, which were underwent PCI . An immunoenzymatic method （ ELISA, Stago Diagnostic） was used to measure the β-thromboglobulin blood plasma concentration. The control group consisted of 35 healthy subjects. Result： Post - procedural levels of β-TG showed a significant decrease compared with preprocedural levels, and then, tended to increase and arrived at the peak at 6 h after PCI. Preprocedural peak levels of β-TG were higher in patients with unstable angina than those in patients with stable angina pectoris. Conclusion： Concentrations of β-TG are increased in patients with CHD due to platelet activation. Intravascular platelet activation showed a dynamic change before and after PCI, and activation of platelet was positively related to stability of plaque and periprocedural myocardial damage.

关 键 词：冠心病 经皮冠状动脉介入治疗 β-血小板球蛋白(β-TG) 

分 类 号：R541.4[医药卫生—心血管疾病]