血管紧张素Ⅱ-2型受体在心脏保护方面的研究进展  

Advances in Research into Angiotensin Ⅱ Type 2 Receptor in Cardiovascular System Protection

作　　者：孟永[1] 李芳[1] 张敏[1] 肖践明[1] 

机构地区：[1]昆明医学院第一附属医院心内科,云南昆明650031

出　　处：《心血管病学进展》2007年第6期921-924,共4页Advances in Cardiovascular Diseases

摘　　要：血管紧张素Ⅱ的大部分心血管效应(如收缩血管、升血压、刺激醛固酮分泌、促进心肌和血管细胞增殖等)是由血管紧张素Ⅱ-1型受体(AT1)介导,但是越来越多的实验结果显示:血管紧张素Ⅱ-2型受体(AT2)具有拮抗AT1的功能,起着对抗细胞生长和心肌肥厚及促细胞分化、凋亡,扩张血管,降低血压等作用,并认为其可能是一种潜在的心脏、血管保护性受体。现就近年来对AT在心脏保护方面的研究进展作一综述。Most of the cardiovascular effects of angiotensin Ⅱ （ systolic blood vessels or blood pressure and stimulation of aldosterone secretion, myocardial and vascular cell proliferation, etc.） are mediated by AT1 , but a growing number of experimental results show that AT2 is the function of AT1 antagonism played against myocardial hypertrophy and promotes cell growth and differentiation, apoptosis, vasodilation, lowering blood pressure, and that it may be a potential cardiovascular protective receptor. This article reviews advances in research into angiotensin Ⅱ type 2 receptor in cardiovascular system protection.

关 键 词：血管紧张素Ⅱ 血管紧张素Ⅱ-2型受体 肾素-血管紧张素系统 心血管系统 

分 类 号：R541[医药卫生—心血管疾病]