牛角地黄冲剂对大鼠内毒素休克的保护作用  

Protective Effect of Niujao Dihuang Granule on Endotoxic Shock in Rats

作　　者：邓常青[1,2] 蒋文明[1,2] 肖苏红 贺蓉 陈筱春 陈大舜[1,2] 贺石林 

机构地区：[1]湖南中医学院 [2]湖南医科大学

出　　处：《中国实验方剂学杂志》1997年第2期23-26,共4页Chinese Journal of Experimental Traditional Medical Formulae

摘　　要：灌胃牛角地黄冲剂，可明显抑制静注内毒素引起的动脉血压的降低，抑制血浆肿瘤坏死因子（ＴＮＦ）和组织因子（ＴＦ）含量的升高，提高其血浆组织因子途径抑制物（ＴＦＰＩ）／组织因子（ＴＦ）比值，并防止休克后血小板数和血浆抗凝血酶Ⅲ（ＡＴ－Ⅲ）活性的降低。Anti shock of Niujao Dihuang granule was investigated by using E.coli endotoxic shock model in rats.Niujao Dihuang granule could markedly inhibited arterial pressure fall induced by injecting endotoxic intravenouly in rats(P<0 01),antagonize contents increase of plasma tumor necrosis factor(TNF) and tissue factor(TF) (P<0 05),enhance tissue factor pathway inhibitor(TFPI)/tissue factor(TF) ratio(P<0 05),and prevented decrease of platelet count and plasma anti thrombinⅢ(AT Ⅲ) activity (P<0 05) in shock rats.

关 键 词：中药品 牛角地黄冲剂 内毒素休克 

分 类 号：R286[医药卫生—中药学] R269.314[医药卫生—中医学]