真性红细胞增多症治愈多年后出现急性单核细胞白血病（M5b）  

After real red blood cell increasing sickness cures many years to appear the acute uninuclear cell leukemia （M5b）

作　　者：王爱芹 于美玉 Wang Aiqin ,Yu Meiyu

机构地区：山东省即墨第二人民医院,266214

出　　处：《中外健康文摘：临床医师》2007年第10期85-86,共2页

摘　　要：白血病分原发性和继发性，化疗药物导致的白血病为继发性白血病，尤以32磷和烷化剂可引起骨髓细胞克隆性染色体异常，主要为五号和七号染色体丢失或长臂不同部分丢失，PV发展缓慢，部分可转化为MDS，骨髓纤维化，急性白血病。目前认为PV转为急性白血病的原因：一方面是应用32磷，羟基脲，烷化剂等治疗相关；另一方面也与疾病自身转化发展有关。因为即使单纯采用放血治疗的患者，也可能有极少部分进展为急性白血病，但发病率比前者大为降低。The leukemia to divide the primary stage and to continue sends the nature, the leukemia which the chemotherapy medicine causes for continues the sending leukemia, especially may cause the marrow cell clone take 32 phosphorus and the alkylating agent chromosome exceptionally, mainly as five and seven chromosomes loses or the long arm different partial losses, PV develops slowly, are partial may transform is MDS, the marrow fibrosis, acute leukemia. At present thought PV transfers the acute leukemia the reason： On the one hand is applies 32 phosphorus, the hydroxy-urea, treatment correlation and so on alkylating agent; On the other hand also concerns with the disease own transformation development. Because patient which even if purely uses the bloodletting treatment, also possibly has extremely little the partial progress is the acute leukemia, but the disease incidence rate greatly for reduces compared to former.

关 键 词：真性红细胞 增多症 急性单核细胞白血病 

分 类 号：R446.11[医药卫生—诊断学;医药卫生—临床医学]