从6-APA和7-ADCA生产废液中回收苯乙酸  

Recovery of Phenyl Acetic Acid from Waste Liquor in 6-APA and 7-ADCA Production

作　　者：李丽娟[1] 于文国[1] 蒋萃岚[1] 张之东[1] 马丽锋[1] 陈慧[1] 

机构地区：[1]河北化工医药职业技术学院制药工程系,河北石家庄050026

出　　处：《化工环保》2007年第3期260-262,共3页Environmental Protection of Chemical Industry

基　　金：河北省教育厅自然科学指导性课题(Z2006417)

摘　　要：采用溶剂萃取、水法提取等方法从6-氨基青霉烷酸和7-氨基-3-去乙酰氧基头孢烷酸生产废液(简称废液)中回收苯乙酸(PAA),考察了各种因素对回收效果的影响。实验结果表明:以甲苯为萃取剂,在萃取温度30℃、萃取时间15m in、500mL废液中萃取剂加入量130mL的最佳条件下,萃取率为96.5%;在提取温度为65℃左右、结晶温度低于10℃的条件下,PAA收率大于89%,纯度大于99%;所得PAA产品质量好,可用于青霉素G等医药产品的生产。Phenyl acetic acid （PAA） was recovered from waste liquor in 6-amino-penicillanic acid and 7-amino-3-desacetoxy cephalosporanic acid production by extraction with solvent and water. The effects of different factors on the recovery were studied. Using toluene as extraction agent and under the optimum conditions of extraction temperature 30 ℃, extraction time 15 rain, extraction agent dosage 130 mL in 500 mL waste liquor, the extraction efficiency is 96.5%. When the water extraction temperature is 65 ℃ and the crystallization temperature is lower than 10 ℃, the yield of PAA is above 89% and the purity is above 99%. The PAA product with good quality can be used in the production of medicine such as penicillin G.

关 键 词：苯乙酸 6-氨基青霉烷酸 7-氨基-3-去乙酰氧基头孢烷酸 回收 

分 类 号：TQ116.2[化学工程—无机化工]