菊藤胶囊对应激性高血压大鼠血压及血液ET、NO含量的影响  

The Influence of Juteng Capsules on Blood Pressure and Plasma ET and Serum NO of Rats with Stress-induced Hypertension

作　　者：孙国芳[1] 王长海[1] 

机构地区：[1]第四军医大学西京医院中医科,西安710032

出　　处：《现代生物医学进展》2007年第11期1651-1653,共3页Progress in Modern Biomedicine

基　　金：陕西省攻关课题

摘　　要：目的:探讨了菊藤胶囊对应激性高血压(SIH)大鼠血压影响的可能机制。方法:采用电击足底应激刺激的方法制备应激性高血压大鼠模型,观察每天应激刺激前灌服菊藤胶囊对应激大鼠血压的影响,检测血清一氧化氮(NO)、血浆内皮素(ET)水平。结果:模型组血压显著升高,模型组与其它各组血压比较差异均有统计学意义(P<0.01)。正常组、卡托组、菊高组之间进行比较,差异无统计学意义(P>0.05);与模型组比较,菊藤胶囊高中剂量组、西药组可使SIH血清NO水平显著升高(P<0.01),高中剂量组、西药组可使血浆ET水平显著下降(P<0.01);正常组、西药组、中药高剂量组之间进行比较并无显著性差异。结论:SIH形成与血清NO水平下降、血浆ET水平升高有关,菊藤胶囊能有效降低血压,其降压机制可能与调整血清NO、血浆ET水平有关。Objective： It was to study the mechanisms on the effect of Juteng Capsules on blood pressure of rats of stress-induced hypertension （SIH） model, Methods： 42 healthy male SD rats were randomly separated into 6 groups： normal group, stressed model group, stressed for Western medicine group, stressed for traditional Chinese medicine high dosage group, middle dosage group, low dosage group, 7 rats in each group, The model of chronic stress induced hypertensive rats （CSIH） was induced by chronic foot-shock in healthy male SD rats. Rats were drenched captopril, at 20 mg/kg, d^-1. in stressed for western medicine group ;rats were drenched Juteng Capsule, at 3 mg/kg.d^-1,1.5 mg/kg .d^-1,0.75 mg/kg .d^-1 in traditional Chinese medicine high, meddle and low dosage group; ap,dest was drenched every day at the same time in normal group and stressed model group. Blood pressure was measured every day, After 4 weeks, blood was taken to separate plasma and serum .The levels of plasma ET were measured by radioirnmunoassay and serum NO, by nitroreductasoassay. Results： In stressed model group, compared with stressed for Western medicine group and stressed for traditional Chinese medicine high dosage group, serum NO degraded significantly （P〈0.01）; plasma ET increased significantly （P〈0.01）; the other groups had not significant differences P〉0.05. Conclusion： Juteng Capsules have distinct function of lowering SIH rat＇s blood pressure, Its mechanism may be close to connectwith regulating the balance between plasma ET and serum NO by descending ET and ascending NO.

关 键 词：菊藤胶囊 应激性高血压 内皮素 一氧化氮 

分 类 号：R2-031[医药卫生—中西医结合] R544.1[医药卫生—中医学]