抗生素对临床常见G^+致病菌的效价分析  

Analysis on the Potency of the Commonly used Antibiotics for G^+ Pathogenic Bacteria

作　　者：李文志[1] 

机构地区：[1]湖南省南华大学第一附属医院,湖南衡阳421001

出　　处：《现代生物医学进展》2007年第11期1701-1703,共3页Progress in Modern Biomedicine

摘　　要：目的:调查我院常用抗G^+致病菌的抗生素的种类效价情况,为抗G^+致病菌的合理用药提供依据。方法:从2978个样本中分离到953株G^+致病菌,用全自动微生物分析仪-VITEK32进行菌种鉴定及16种抗生素的药敏实验。结果:953株G^+致病菌经鉴定属于11大类,其中金黄色葡萄球菌、表皮葡萄球菌、溶血葡萄球菌、草绿色链球菌和肠球菌属是五类主要的G^+致病菌,依次分别占总分离量的30.3%、17.3%、15.1%、9.8%和6.8%;在检测的16种抗生素对排在前五位的G^+致病菌的平均效价最低的五类抗生素是:青霉素(24.22%)、红霉素(26.22%)、头孢唑林(28.06%)、与链霉素(30.52%)和庆大霉素(31.06%)。而抗G^+致病菌整体效果最好的是:螯合新泰林(93.72%)、万古霉素(82.62%)和四环素(78.68%)。结论:研究结果表明越来越多抗生素抗临床常见G^+致病菌的效价呈现逐年递减的趋势。ABSTRACT Objective： In order to provide the data resource for rational administration to resist pathogenic bacteria G^＋, we have researched the category potency of the commonly used antibiotics against pathogenic bacteria G^＋ in our hospital. Methods： 953 stains of the pathogenic bacteria G^＋ have been segregated from 2978 samples, then the automatic microbion analysator VITEK 32 was used to identify strains and test the drug susceptibility of 16 antibiotics. Results： 953 strains of pathogenic bacteria G^＋ belong to 11 categories. Staphylococcus aureus, Staphylococcus epidermidis, hemolysis Staphylococcus, Streptococcus viridans and enterococcus are five main kinds of pathogenic bacteria G^＋, accounting for 30.3%, 17.3%, 15.1%, 9.8% and 6.8%, respectively. Among the 16 kinds of antibiotics tested, penicillin （24.22%）, illotycin （26.22%）, cephazolin （28,06%）, phytomycin （ 30.52% ） and cidomycin （ 31.06% ） are five kinds of antibiotics with the lowest average potency for pathogenic bacteria G^＋. The antibiotics with an entirely best potency are chelat-new-Tailin （93.72%） vancocin（ 82.62% ） and ambramycin（ 78.68% ）. Conclusion： the results showed that more and more antibiotics for pathogenic bacteria G^＋ has a potency of gradually decreased tendency.

关 键 词：抗生素 药物监测 耐药性 G^+致病菌 

分 类 号：R117[医药卫生—公共卫生与预防医学]