20(S)-原人参二醇组皂苷的制备及其转化制取人参皂苷Rh2  

Preparation of 20(S) protopanaxadiol saponins and 20(S) ginsenoside Rh 2 from 20(S) protopanaxadiol saponins

作　　者：陈燕萍[1] 孟勤[1] 宋长春[1] 马兴元[1] 王广树[1] 徐景达[1] 

机构地区：[1]白求恩医科大学基础医学院

出　　处：《中国药学杂志》1997年第5期273-275,共3页Chinese Pharmaceutical Journal

摘　　要：目的：制取２０（Ｓ）原人参二醇组皂苷并将其转化制备抗癌活性单体２０（Ｓ）人参皂苷Ｒｈ２。方法：以国产西洋参茎叶总皂苷为原料，通过萃取法制备２０（Ｓ）原人参二醇组皂苷；将２０（Ｓ）原人参二醇组皂苷碱催化水解后，经柱层析分离纯化制备２０（Ｓ）人参皂苷Ｒｈ２。结果：２０（Ｓ）原人参二醇组皂苷收率为４１．５％，其转化成２０（Ｓ）人参皂苷Ｒｈ２的转化率为９．６４％。结论：制取方法简便，收率较高。OBJECTIVE: To prepare 20(S) protopanaxadiol saponins and change them into 20(S) ginsenoside Rh 2 having antitumor activity. METHODS: From the crude saponins of the stems and leaves of American ginseng grown in China, we prepared 20(S) protopanaxadiol saponins by extraction and 20(S) ginsenosiok Rh 2 by the alkaline hydrolysis of protopanaxadiol saponins and column chromatography. RESULTS: The yield of 20(S) protopanaxadiol saponins was 41.5%, and the yield of 20(S) ginsenoside Rh 2 was 9.64% from the 20(S) protopanaxadiol saponins.CONCLUSION: The method is simple and has a high yield.

关 键 词：皂苷 西洋参 人参皂苷-Rh2 制备 

分 类 号：R284.2[医药卫生—中药学]