氟噻草胺的合成  

Synthesis of Flufenacet

作　　者：姜育田[1] 陈同明[1] 李茂青[1] 

机构地区：[1]江苏安邦电化有限公司,江苏淮安223002

出　　处：《农药》2007年第11期734-736,共3页Agrochemicals

摘　　要：改进了除草剂氟噻草胺的合成方法。以肼基二硫代甲酸甲酯、三氟乙酸为原料合成2-甲砜基-5-三氟甲基-1,3,4-噻二唑(4),反应收率81.5%;以对氟硝基苯、丙酮经过催化加氢、酰化、醇解合成N-(4-氟苯基)-N-异丙基-2-羟甲基乙酰胺(8)。化合物(4)与(8)反应合成氟噻草胺,得率94.2%。改进后的工艺反应条件温和,三废少,产品纯度和收率高。Herbicide flufenacet was synthesized by reaction of 2-（methylsulfonyl）-5-（trifluoromethyl）-l,3,4-thiadiazole with N-（4-fluorophenyl）-2-hydroxy-N-isopropylacetamide with the yield of 94.2%. 2-（Methylsulfonyl）-5- （trifluoromethyl）-l,3,4-thiadiazole was prepared by reaction of methyl hydrazinecarbodithioate with trifluoroacetic acid with the yield of 81.5%. N-（4-Fluorophenyl）-2-hydroxy-N-isopropylacetamide was synthesized by using l-fluoro-4-nitrobenzene as a starting material in four-step procedure.

关 键 词：氟噻草胺 合成 除草剂 

分 类 号：TQ457[化学工程—农药化工]