现代电休克治疗对重度抑郁自杀患者的临床疗效  

Effect of modified electroconvulsive therapy on suicide in major depressed patients

作　　者：胡永东[1] 

机构地区：[1]北京大学精神卫生研究所,北京100083

出　　处：《中国行为医学科学》2007年第11期993-994,共2页Chinese Journal of Behavioral Medical Science

摘　　要：目的观察现代电休克治疗（MECT）对重度抑郁自杀患者的临床疗效。方法20例未用抗抑郁药的重度抑郁自杀患者,经2周、6次MECT,用汉密尔顿抑郁量表（HAM-D）自杀项评定疗效。结果重度抑郁自杀患者MECT急性治疗2周后的HAM-D自杀项评分[（0.25±0.72）分]、HAM-D总分[（6.20±3.81）分]与治疗前评分[分别为（2.95±0.95）分,（31.25±5.25）分]的差异有显著性。HAM-D自杀项减分率（Y）与HAM-D总分减分率（X）存在正相关关系（相关系数r=0.587,P〈0.01）,其直线回归方程：Y=-66.707＋1.894X（P〈0.01）。结论MECT对重度抑郁患者的自杀有效,而且自杀水平可能随着抑郁的好转而减低。Objective To observe the efficiency of modified electroconvulsive therapy（MECT） on suicide in major depressed patients. Methods In this study, score of suicide item and total scores of Hamilton Rating Scale for Depression（HAM-D） were compared in major depressed patients（n=20） associated with suicide before and after 2 weeks,6 times of MECT. Results After 2 weeks of MECT, score of suicide item and total scores of HAM-D of patients（0.25 ±0.72 ; 6.20± 3.81, respectively） had decreased significantly （ P 〈 0.01 ; P 〈 0.01, respectively） and better than those of Baseline （2.95 ± 0.95 ; 31.25 ± 5.25, respectively）. Furthermore, the decrease rate of score of suicide item （Y） were positively correlated with that of total scores （X） （ r = 0. 587, P 〈 0.01） and the linear regression equation： Y= -66.707 ±1.894X （P〈0.01）. Conclusion These results support that MECT may be effective to suicide in major depressive disorder and initially suicide levels will decrease parallel with their efficiency of antidepression.

关 键 词：现代电休克治疗 自杀 重度抑郁 

分 类 号：R686[医药卫生—骨科学]