几种动物病原菌对替米考星耐药性的体外诱导  

Resistance Induction of Tilmicosin on a Few of Animal Pathogenic Bacteria in Vitro

作　　者：吴聪明[1] 王建国[1] 王绍琛[1] 柳焜耀[2] 沈建忠[1] 

机构地区：[1]中国农业大学动物医学院,北京100094 [2]中国兽医药品监察所,北京100081

出　　处：《中国兽药杂志》2007年第11期12-16,共5页Chinese Journal of Veterinary Drug

基　　金：国家自然科学基金(30571401)

摘　　要：在测定替米考星对鸡毒支原体、多杀巴氏杆菌和猪胸膜肺炎放线杆菌的最小抑菌浓度基础上，采用药物浓度递增法体外诱导3种病原菌对替米考星的耐药性。结果鸡毒支原体经9次传代对替米考星产生了高水平耐药，多杀巴氏杆菌经7～9次传代对替米考星产生了高水平耐药，猪胸膜肺炎放线杆菌经14次传代对替米考星的耐受浓度未发生明显变化；鸡毒支原体和多杀巴氏杆菌替米考星诱导耐药株对红霉素、阿奇霉素、泰乐菌素、吉他霉素和林可霉素表现交叉耐药。研究结果提示，替米考星较易诱导鸡毒支原体和多杀巴氏杆菌产生耐药性，兽医临床应合理应用。Induction of tilmicosin resistance in Mycoplasma gallisepticum （MG）, Pasteurella multocida （ PM ） and （App） were performed by in vitro exposure to stepwise concentration of tilmicosin, and the MICs of macrolides and lincomycin for tilmicosin - resistant mutants were determined. High resistance to tilmicosin appeared after 9 passages in MG and after 7 - 9 passages in PM . But for App, the tolerated concentration of tilmicosin was unchanged for 14 passages. All tilmicosin - resistant mutants of MG and App were cross- resistant to erythromycin, azithromycin, tylosin, kitasamycin and lincomycin. These results indicated that development of resistance to tilmicosin in MG and PM might be a relatively frequent event, so it is necessary to use tilmicosin in treatments cautiously.

关 键 词：鸡毒支原体 多杀巴氏杆菌 胸膜肺炎放线杆菌 替米考星 耐药性 

分 类 号：S859.796[农业科学—临床兽医学]