作用于细菌蛋白质合成的全合成抗菌剂研究进展  

Progress of Research on Antibacterial Agents Inhibiting Bacterial Protein Synthesis

作　　者：周伟澄[1] 

机构地区：[1]上海医药工业研究院,上海200437

出　　处：《中国医药工业杂志》2007年第11期805-813,共9页Chinese Journal of Pharmaceuticals

基　　金：上海市科委基金(07DZ22002;07XD14205)

摘　　要：肽脱甲酰基酶抑制剂和噁唑烷酮类抗菌剂是近年来新型全合成抗菌药的研究热点,它们都作用于细菌蛋白质的合成。本文综述了这两类抗菌剂近年来结构修饰及构效关系的研究进展,为进一步的新药研究提供参考。Both the inhibitors of peptide deformylase and oxazolidinones are the foci on the research of novel totally-synthesized antibacterial agents which function by blocking the protein synthesis in bacterial cells. In the paper, the structural modification and structure-activity relationship of these two types of antibacterials are reviewed in order to give some references for the further research.

关 键 词：肽脱甲酰基酶 抑制剂 噁唑烷酮 抗菌剂 蛋白质合成 综述 

分 类 号：R978[医药卫生—药品]