新结构类型抗真菌先导化合物的研究进展  

Recent advances in the study of antifungal lead compounds with new chemical scaffolds

作　　者：邵律成[1] 盛春泉[1] 张万年[1] 

机构地区：[1]第二军医大学药学院,上海200433

出　　处：《药学学报》2007年第11期1129-1136,共8页Acta Pharmaceutica Sinica

基　　金：国家自然科学基金重点项目(30430750).

摘　　要：近年来深部真菌感染率不断升高,而目前临床上现有的抗真菌药物均存在较大缺陷,难以满足治疗所需,因此寻找全新结构类型和全新作用机制抗真菌先导化合物对研发新一代抗真菌药物具有重要意义。本文综述了近年来新报道的抗真菌先导化合物,详细讨论了它们的化学结构、抗真菌活性和构效关系,并评述了它们的现有问题和未来发展方向。In recent years, the incidence of infections caused by invasive fungal pathogens has increased dramatically. However, most antifungal agents used in clinic have many drawbacks and cannot meet the demand of the clinical use. Therefore, for the development of new generation of antifungal agents, it is of great significance to find antifungal lead compounds with novel chemical scaffolds and new mode of action. Novel antifungal lead compounds reported in recent years are reviewed. Their chemical structures, antifungal activity and structure-activity relationship are discussed in detail, and current problems and trends in future research are also emphasized.

关 键 词：抗真菌 先导化合物 构效关系 

分 类 号：R916[医药卫生—药学]