三苯双脒肠溶片治疗899例儿童肠道线虫感染的临床观察  

Clinical Observation on 899 Children Infected with Intestinal Nematodes and Treated with Tribendimidine Enteric Coated Tablets

作　　者：肖树华[1] 吴中兴[2] 张剑辉[3] 王善清[4] 王世海[5] 邱东川[6] 王翀[3] 

机构地区：[1]中国疾病预防控制中心寄生虫病预防控制所,世界卫生组织疟疾,血吸虫病和丝虫病合作中心,上海200025 [2]江苏省寄生虫病防治研究所,无锡214064 [3]山东新华制药股份有限公司,淄博255005 [4]海南省疾病预防控制中心,海口570203 [5]贵州省疾病预防控制中心,贵阳550001 [6]四川省疾病预防控制中心,成都610031

出　　处：《中国寄生虫学与寄生虫病杂志》2007年第5期372-375,共4页Chinese Journal of Parasitology and Parasitic Diseases

摘　　要：目的评价三苯双脒肠溶片(200mg)治疗4～14岁儿童钩虫和蛔虫感染者的安全性和疗效。方法在海南、四川和贵州等3个临床试验中心进行三苯双脒肠溶片开放临床试验,受治者用改良加藤法(Kato-Katz)粪检确诊为钩虫、蛔虫感染,钩虫与蛔虫混合感染或合并鞭虫感染等,共收治4～14岁儿童899例,采用三苯双脒肠溶片200mg单剂口服治疗,观察不良反应,并于治疗后3～4周用相同方法作粪检评价治疗效果。结果三苯双脒肠溶片200mg对儿童钩虫感染的治愈率及有效率分别为82.0%(433/528)和99.2%(524/528);对蛔虫感染的治愈率及有效率分别为90.1%(576/639)和99.7%(637/639),而鞭虫感染治愈率仅为36.8%(112/304)。儿童顿服三苯双脒肠溶片200mg的不良反应轻微和短暂,总的不良反应率为1.6%(14/899),主要为头晕、恶心和呕吐等。血、尿常规,肝、肾功能和心电图检查未见明显影响。结论三苯双脒肠溶片200mg治疗儿童钩虫和蛔虫感染的疗效显著,不良反应率低。Objective To evaluate the efficacy and safety of tribendimidine in treatment of children with hookworm and Ascaris lumbricoides infections. Methods An open and multi-center clinical trial was conducted in the provinces of Hainan, Sichuan and Guizhou. 899 children aged 4-14 years were enrolled in the study. Hookworm, A. lumbircoides or other helminth infections were diagnosed by improved Kato-Katz method. All the patients were treated orally with tribendimidine enteric coated tablet at a single dose of 200 mg. The efficacy was evaluated by stool examination 3--4 weeks post treatment. Results The cure rate and effective rate of the children with hookworm infection were 82.0%（433/528） and 99.2%（524/528）, respectively, while in children with A.lumbricoides infection, they were 95.0%（576/639） and 99.8% （637/639）, respectively. The efficacy of tribendimidine enteric coated tablet given to the children with Trichuris trichiura infection at a single dose of 200 mg was 36.8%（112/304）. The adverse effect induced by tribendimidine, such as dizziness, nausea and vomiting, was light and transient with an adverse effect rate of 1.6% （14/899）. No apparent impact was seen on the blood and urine routine examination, hepatic and renal function as well as ECG examination. Conclusion Tri- bendimidine given at a single dose of 200 mg exhibits lower adverse effect rate and potential efficacy in the treatment of children with hookworm and A.lumbricoides infections.

关 键 词：三苯双脒 钩虫 蛔虫 鞭虫 疗效 安全性 

分 类 号：R532.1[医药卫生—内科学]