氯代水杨胺灭螺效果的实验研究  

Study on Molluscicidal Effect of Chlorosalicylicamide

作　　者：金伟[1] 杜金奎[1] 元艺[2] 魏凤华[2] 刘伟[1] 王辉[1] 李桂玲[1] 徐兴建[2] 

机构地区：[1]华中科技大学,武汉430030 [2]湖北省疾病预防控制中心血吸虫病防治研究所,武汉430079

出　　处：《中国寄生虫学与寄生虫病杂志》2007年第5期411-414,共4页Chinese Journal of Parasitology and Parasitic Diseases

基　　金：国家863高技术发展计划(No.2004AA2Z3560)~~

摘　　要：目的观察氯代水杨胺的灭螺效果和对鱼苗的毒性。方法配制不同浓度的氯代水杨胺,用浸泡法、喷洒法观察不同浓度和不同作用时间的灭螺效果,并进行鱼苗毒性实验。氯硝柳胺乙醇胺盐作对照。结果氯代水杨胺的浓度为0.25和0.5mg/L,浸泡48h,钉螺死亡率分别为97.8%、100%,半数有效致死浓度(LC50)为0.0674mg/L;氯硝柳胺乙醇胺盐浓度为0.25和0.5mg/L,浸泡48h,钉螺死亡率分别为22.2%、66.7%,LC50为0.3976mg/L。药物浓度为0.4mg/L喷洒1、3、7和15d,氯代水杨胺的灭螺率分别为90%、100%、100%和100%;氯硝柳胺乙醇胺盐的灭螺率分别为60%、70%、70%和50%。0.25mg/L浸泡48h,氯代水杨胺和氯硝柳胺乙醇胺盐刺激钉螺离水上爬率分别为32.2%和46.7%。0.4mg/L药物作用72h,氯代水杨胺和氯硝柳胺乙醇胺盐的鱼苗死亡率分别为50.0%和100%。结论氯代水杨胺有灭钉螺作用,对鱼苗毒性比氯硝柳胺乙醇胺盐略低,并有抑制钉螺上爬作用。Objective To observe the molluscicidal effect of chlorosalicylicamide on Oncomelania hupensis and toxicity on fishes. Methods Different concentrations of chlorosalicylicamide were prepared, and immersion and spraying methods were used to test its molluscicidal effect and toxicity to fishes. Niclosamide ethanolamine salt was used as control. Results Under water temperature of 28 ℃ with the dose of chlorosalicylicamide at 0.25 mg/L and 0.4 mg/L, the mortality rate of snails by immersion was 97.8% and 100% respectively after 48 h, and the LC50 was 0.067 4 mg/L. While for niclosamide at the same doses, the mortality rate of snails was 22.2% and 66.7% respectively, and the LCso was 0.397 6 mg/L. With the concentration of 0.4 mg/L for 72 h, the fish death rate in chlorosalicylicamide and niclosamide was 50.0% and 100% respectively. Conclusion Chlorosalicylicamide shows a molluscicidal effect on Oncomelania snails and a lower toxicity to fishes than that of niclosamide.

关 键 词：氯代水杨胺 氯硝柳胺乙醇胺盐 钉螺 灭螺药物 

分 类 号：R383.241[医药卫生—医学寄生虫学]