格列齐特分散片处方及制备工艺研究  

Optimization of Formula and Preparation Technology of Gliclazide Dispersible Tablets

作　　者：许军[1] 彭红[1] 王路华[1] 赵德芳[1] 

机构地区：[1]江西中医学院,江西南昌330004

出　　处：《时珍国医国药》2007年第11期2671-2672,共2页Lishizhen Medicine and Materia Medica Research

摘　　要：目的考察及筛选格列齐特分散片的制备工艺和处方。方法通过系列实验筛选崩解剂等辅料,确定处方及制备工艺,比较了分散片及普通片剂中主药的溶出度。结果确定了以交联羧甲基纤维素钠、交联聚乙烯吡咯烷酮作为崩解剂的分散片处方;分散片溶出速率较普通片快。结论格列齐特分散片处方合理、工艺可行,符合分散片的要求。Objective To optimize the preparation technology and the formula of Gliclazide dispersible tablets. Methods The formula and preparation process were optimized by a series of experiments. The dissolution rates of the principal agent in dispersible tablets and conventional tablets were determined and compared. Results Sodium carboxymethyl starch and crospolyvinylpyrrolidone were optimized as the disintegrants of the dispersible tablet formula;the dissolution rates of the dispersible tablets were faster than those of the conventional tablets. Conclusion The prepared gliclazide dispersible tablet is reasonable in formula, feasible in technology and it meets the quality standards.

关 键 词：格列齐特 分散片 处方 制备工艺 

分 类 号：R943[医药卫生—药剂学]