格列齐特固体共熔体的热分析研究  

Thermoanalysis of the Solid Dispersion of Gliclazide

作　　者：彭红[1] 赵德芳[1] 王路华[1] 许军[1] 

机构地区：[1]江西中医学院,江西南昌330004

出　　处：《时珍国医国药》2007年第11期2797-2798,共2页Lishizhen Medicine and Materia Medica Research

摘　　要：目的通过热分析技术证实共熔体的形成。方法按照差示扫描量热分析(DSC)和热重分析(TG)方法分别测定乳糖、格列齐特以及乳糖和格列齐特不同比例混合样。结果DSC曲线和TG曲线证明乳糖和格列齐特一定比例下形成共熔体。结论乳糖和格列齐特一定比例下经高速研磨混合的样品形成了共熔体;采用该工艺技术可显著提高难溶性药物主药格列齐特的溶出速率。Objective To illustrate the preparation of Gliclazide dispersible tablets by thermoanalysis technology. Methods To determine Galactosylglucose, Gliclazide and the different proportion of Galactosylglucose and Gliclazide according to the methods of different scanning colorimetry（DSC） and mogravimetry（TG）, Results From the graphs of DSC and TG , solid dispersion was formed in the procedure. Conclusion The sample of Galactosylglucose and Gliclazide can form solid dispersion by high speed grinding. The dissolution rate of Gliclazide can be significantly improved by this technology.

关 键 词：格列齐特 固体共熔体 差示扫描量热分析 热重分析 

分 类 号：R943[医药卫生—药剂学]