动物体内植入镁合金的早期实验研究  

EXPERIMENTAL STUDY OF IN VIVO IMPLANTATION OF A MAGNESIUM ALLOY AT EARLY STAGE

作　　者：张广道[1] 黄晶晶[2] 杨柯[2] 张炳春[2] 艾红军[1] 

机构地区：[1]中国医科大学附属口腔医院,沈阳110002 [2]中国科学院金属研究所,沈阳110016

出　　处：《金属学报》2007年第11期1186-1190,共5页Acta Metallurgica Sinica

摘　　要：将不同形态AZ31B镁合金植入实验动物(兔子)体内,并以钛合金作对照组,研究了镁合金对实验动物的影响及其在实验动物体内的降解行为.研究结果表明,镁合金植入2周后,植入物周围有骨痂生成;8周后生成成熟的骨组织.镁合金植入并未对动物机体的循环、免疫、泌尿系统产生负面影响,体内降解产物主要为钙镁磷灰石,可经肾脏代谢,血液中的镁离子浓度在正常值范围内波动.本实验研究证明,镁合金植入动物体内在早期阶段对动物是安全的,且有诱导机体新骨生成的作用.In order to study both the effect and the degradation behavior of magnesium alloys on/in animals, AZ31B magnesium alloys with different dimensions were implanted in the New-Zealand rabbits, and compared with a titanium alloy （Ti-6Al-4V） as a control material. It was found from the experiments that the osteotylus was formed surround the magnesium alloy implant after 2 weeks, which was turned into ripe bone tissue after 8 weeks. The implantation of the magnesium alloy did not show negative influence on the recirculating, immune and urinary systems of the rabbits. Magnesium calcium apatite, which was the main degradation product of the magnesium alloy, could be metabolismed by the kidney. Magnesium ion concentration in the blood was in the range of normal values. It can be concluded that the magnesium alloy implantation is safe for rabbits at the early stage, and the implant can be beneficial to the new bone formation.

关 键 词：金属基生物材料 镁合金 可吸收材料 骨 

分 类 号：TG146[一般工业技术—材料科学与工程]