中药治疗小白鼠破伤风实验研究  

Experimental Study on Treatment of Mice Bearing Tetanus with Traditional Chinese Medicine

作　　者：丁宁[1] 孙海涛[2] 林蔚[2] 张小凤[2] 丁庆社[3] 杨宗琪[4] 

机构地区：[1]川北医学院麻醉学系 [2]川北医学院临床医学系 [3]川北医学院影像系 [4]川北医学院基础医学院病原中心,四川省南充市637000

出　　处：《医学理论与实践》2007年第11期1244-1245,共2页The Journal of Medical Theory and Practice

摘　　要：目的:探讨中药治疗小白鼠破伤风的实验方法及所选中药对小白鼠破伤风的治疗和预防效果。方法:厌氧培养破伤风梭菌,提取破伤风毒素。将90只小白鼠随机分成3组;给实验A1组和实验A2组中药灌胃,再分别于50min和120min后,肌肉注射破伤风痉挛毒素,对照组(B组)生理盐水灌胃50min后肌肉注射破伤风痉挛毒素。观察实验组和对照组小白鼠的发病及死亡情况。结果:实验组的死亡率、注射毒素-发病时间、痉挛强度与对照组的差异有统计学意义(P<0.05)。结论:所选中药对小白鼠破伤风有预防和治疗作用。　Objective： To explore the experimental methods of therapy and effectiveness of TCM for mice bearing tetanus.Methods： Tetanus bacillus was anaerobiously cultured to obtain the tetanospasmin.Ninety mices were divided into 3 groups randomly.Mices of experimental groups（groupA1 and groupA2） were perfused with TCM,and 50 min and 120 min later,given intramuscular injection of tetanospasmin respectively.Mices of control group were perfused with normal saline,and 50 min later,given intramuscular injection of tetanospasmin.And then the pathogenic condition and death rate of experimental groups and the control group were observed.Results：The death rate,the toxin injection-occuring time,and spasm intensity of the experimental groups had significant difference in statistics from the control group（P〈0.05）.Conclusion：The chosen TCM have functions of prevention and treatment on subjects.

关 键 词：中药治疗 小白鼠 破伤风 痉挛 死亡率 

分 类 号：R633.1[医药卫生—外科学]