甲型流感病毒感染BALB/c鼠动物模型的建立  

The model of influenza virus A infection in BALB/c Mice

作　　者：张烜榕[1] 王涛[1] 申元英[1] 李威[1] 李强[1] 

机构地区：[1]大理学院基础医学院微生物学与免疫学教研室,云南大理671000

出　　处：《大理学院学报（综合版）》2007年第10期25-27,共3页Journal of Dali University

摘　　要：目的:建立甲型流感病毒感染BALB/c鼠动物模型,为研究病毒变异、致病机制及抗病毒药物筛选提供模型动物。方法:通过滴鼻的方法将甲型流感病毒感染到BALB/c鼠,观察小鼠的症状和组织病理改变。结果:BALB/c鼠的临床症状明显,病理变化典型。结论:甲型流感病毒感染BALB/c鼠的疾病模型建成。Objective： To establish an influenza virus A infection model in BALB/c mice and to provide animal model for studying variation, pathogenic mechanism and anti-virus medicines screening. Method： The experimental mice were infected with influenza virus A. Then the clinical symptoms and the histopathological changes were observed. Result： The BALB/c mice had the clinical symptoms and typical lesion. Conclusion： The influenza virus A infected BALB/c mice model can be made.

关 键 词：流感病毒 BALB/C鼠 动物模型 

分 类 号：R373.13[医药卫生—病原生物学]